Changes in lipoprotein composition in hypertriglyceridemic patients taking cholesterol-free fish oil supplements

Masahiro Inagaki, William Harris

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Fish oils rich in n - 3 fatty acids (FAs) have been shown to markedly lower levels of very low density lipoproteins (VLDL), but not the low density lipoproteins (LDL) which are derived from VLDL. Changes in the size and chemical composition of lipoproteins may affect their metabolism. In order to examine the effects of n - 3 FAs on lipoprotein metabolism, 6 patients with hypertriglyceridemia were given 6 g n - 3 FAs/day. Plasma lipid and apoprotein (apo A-I, A-II, B, E, C-II, C-III) levels (mg/dl) were measured before and after 4 weeks of treatment. Changes in lipoprotein size were assessed by gel chromatography. n - 3 FAs lowered VLDL cholesterol (58 ± 35 to 40 ± 30, P <0.01) and total triglyceride (410 ± 170 to 236 ± 114, P <0.01). In spite of this, LDL cholesterol levels did not decrease, and apo B levels increased (98 ± 28 to 111 ± 27, P <0.05). HDL cholesterol rose (31 ± 5 to 34 ± 7, P <0.05). The lipid content of smaller VLDL particles was reduced by over 40%, but the protein content was largely unchanged. Large triglyceride-rich lipoprotein particles were reduced to a greater extent than were small particles. These changes in VLDL particle size and composition may enhance the synthesis of LDL in hypertriglyceridemic patients taking n - 3 FA supplements.

Original languageEnglish (US)
Pages (from-to)237-246
Number of pages10
JournalAtherosclerosis
Volume82
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Fish Oils
Omega-3 Fatty Acids
VLDL Lipoproteins
Lipoproteins
Cholesterol
LDL Lipoproteins
Triglycerides
Lipids
VLDL Cholesterol
Apoproteins
Hypertriglyceridemia
Apolipoprotein A-I
Apolipoproteins B
Particle Size
LDL Cholesterol
HDL Cholesterol
Gel Chromatography
Proteins

Keywords

  • Cholesterol
  • Docosahexaenoic acid
  • Eicosapentaenoic acid
  • Fish oil
  • HDL
  • LDL
  • Lipoproteins
  • Triglycerides
  • VLDL

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Changes in lipoprotein composition in hypertriglyceridemic patients taking cholesterol-free fish oil supplements. / Inagaki, Masahiro; Harris, William.

In: Atherosclerosis, Vol. 82, No. 3, 1990, p. 237-246.

Research output: Contribution to journalArticle

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