Changes in LDL density across the menopausal transition

M. C. Carr, K. H. Kim, A. Zambon, E. S. Mitchell, N. F. Woods, C. P. Casazza, Jonathan Purnell, J. E. Hokanson, J. D. Brunzell, R. S. Schwartz

Research output: Contribution to journalArticle

65 Scopus citations


Background: The risk of coronary artery disease increases in women after menopause. This increased risk may be associated with alterations in the lipid profile characterized by changes in LDL particle size and buoyancy. Characterization of lipoprotein levels and LDL buoyancy across the stages of the menopausal transition has yet to be reported. Methods: Plasma lipoprotein concentrations, LDL buoyancy, and body mass index (BMI) were studied cross-sectionally in five groups of women: premenopausal women (n=42), women in early menopausal transition (n =35), middle menopausal transition (n=19), late menopausal transition (n=20), and postmenopausal women (n= 14). No women were taking estrogen. Results: The postmenopausal women had significantly higher low-density lipoprotein cholesterol (LDL-C) and total cholesterol than premenopausal women (P

Original languageEnglish (US)
Pages (from-to)245-250
Number of pages6
JournalJournal of Investigative Medicine
Issue number4
Publication statusPublished - 2000
Externally publishedYes



  • Cholesterol
  • LDL density
  • Lipoprotein
  • Menopausal transition

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Carr, M. C., Kim, K. H., Zambon, A., Mitchell, E. S., Woods, N. F., Casazza, C. P., ... Schwartz, R. S. (2000). Changes in LDL density across the menopausal transition. Journal of Investigative Medicine, 48(4), 245-250.