Change in cognitive functioning associated with ApoE genotype in a community sample of older adults

Scott Hofer, Helen Christensen, Andrew J. Mackinnon, Ailsa E. Korten, Anthony F. Jorm, Alexander S. Henderson, Simon Easteal

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Abstract

The influence of a genetic risk factor, apolipoprotein E (apoE) ε4 variant, was assessed in older adults aged 70 to 94 on 3 occasions over 7 years. The results of latent growth curve analyses are reported for individuals genotyped for apoE at the 2nd measurement occasion (n = 601) and for a subsample of individuals without probable or definite dementia during the 1st or 2nd occasion (n = 434). ApoE-ε4 status was a significant predictor of level and change in memory performance and change in speed performance in the full sample, and of initial level and change in memory performance in the nondemented subsample. These results support previous findings that apoE-ε4 is associated with accelerated memory deterioration in individuals without clinical dementia.

Original languageEnglish (US)
Pages (from-to)194-208
Number of pages15
JournalPsychology and Aging
Volume17
Issue number2
DOIs
Publication statusPublished - 2002
Externally publishedYes

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ASJC Scopus subject areas

  • Aging
  • Psychiatry and Mental health
  • Developmental and Educational Psychology
  • Experimental and Cognitive Psychology

Cite this

Hofer, S., Christensen, H., Mackinnon, A. J., Korten, A. E., Jorm, A. F., Henderson, A. S., & Easteal, S. (2002). Change in cognitive functioning associated with ApoE genotype in a community sample of older adults. Psychology and Aging, 17(2), 194-208. https://doi.org/10.1037/0882-7974.17.2.194