TY - JOUR
T1 - Change in cognitive functioning associated with ApoE genotype in a community sample of older adults
AU - Hofer, Scott M.
AU - Christensen, Helen
AU - Mackinnon, Andrew J.
AU - Korten, Ailsa E.
AU - Jorm, Anthony F.
AU - Henderson, Alexander S.
AU - Easteal, Simon
PY - 2002
Y1 - 2002
N2 - The influence of a genetic risk factor, apolipoprotein E (apoE) ε4 variant, was assessed in older adults aged 70 to 94 on 3 occasions over 7 years. The results of latent growth curve analyses are reported for individuals genotyped for apoE at the 2nd measurement occasion (n = 601) and for a subsample of individuals without probable or definite dementia during the 1st or 2nd occasion (n = 434). ApoE-ε4 status was a significant predictor of level and change in memory performance and change in speed performance in the full sample, and of initial level and change in memory performance in the nondemented subsample. These results support previous findings that apoE-ε4 is associated with accelerated memory deterioration in individuals without clinical dementia.
AB - The influence of a genetic risk factor, apolipoprotein E (apoE) ε4 variant, was assessed in older adults aged 70 to 94 on 3 occasions over 7 years. The results of latent growth curve analyses are reported for individuals genotyped for apoE at the 2nd measurement occasion (n = 601) and for a subsample of individuals without probable or definite dementia during the 1st or 2nd occasion (n = 434). ApoE-ε4 status was a significant predictor of level and change in memory performance and change in speed performance in the full sample, and of initial level and change in memory performance in the nondemented subsample. These results support previous findings that apoE-ε4 is associated with accelerated memory deterioration in individuals without clinical dementia.
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U2 - 10.1037/0882-7974.17.2.194
DO - 10.1037/0882-7974.17.2.194
M3 - Article
C2 - 12061406
AN - SCOPUS:0036260556
SN - 0882-7974
VL - 17
SP - 194
EP - 208
JO - Psychology and Aging
JF - Psychology and Aging
IS - 2
ER -