Change in Cognitive Capabilities in the Oldest Old

The Effects of Proximity to Death in Genetically Related Individuals over A 6-Year Period

Boo Johansson, Scott Hofer, Jason C. Allaire, Mildred M. Maldonado-Molina, Andrea M. Piccinin, Stig Berg, Nancy L. Pedersen, Gerald E. McClearn

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Change in cognitive abilities was assessed over a 6-year period in a sample of monozygotic and same-sex dizygotic twin pairs (N = 507 individuals), aged 80 and older (mean age = 83.3 years: SD = 3.1), who remained nondemented over the course of the study. Latent growth models (LGMs) show that chronological age and time to death are consistent predictors of decline in measures of memory, reasoning, speed, and verbal abilities. Multivariate LGM analysis resulted in weak and often negative correlations among rates of change between individuals within twin pairs, indicating greater differential change within twin pairs than occurs on average across twin pairs. These findings highlight several challenges for estimating genetic sources of variance in the context of compromised health and mortality-related change.

Original languageEnglish (US)
Pages (from-to)145-156
Number of pages12
JournalPsychology and Aging
Volume19
Issue number1
DOIs
StatePublished - Mar 2004
Externally publishedYes

Fingerprint

Aptitude
Dizygotic Twins
Growth
Mortality
Health

ASJC Scopus subject areas

  • Aging
  • Psychiatry and Mental health
  • Developmental and Educational Psychology
  • Experimental and Cognitive Psychology

Cite this

Change in Cognitive Capabilities in the Oldest Old : The Effects of Proximity to Death in Genetically Related Individuals over A 6-Year Period. / Johansson, Boo; Hofer, Scott; Allaire, Jason C.; Maldonado-Molina, Mildred M.; Piccinin, Andrea M.; Berg, Stig; Pedersen, Nancy L.; McClearn, Gerald E.

In: Psychology and Aging, Vol. 19, No. 1, 03.2004, p. 145-156.

Research output: Contribution to journalArticle

Johansson, Boo ; Hofer, Scott ; Allaire, Jason C. ; Maldonado-Molina, Mildred M. ; Piccinin, Andrea M. ; Berg, Stig ; Pedersen, Nancy L. ; McClearn, Gerald E. / Change in Cognitive Capabilities in the Oldest Old : The Effects of Proximity to Death in Genetically Related Individuals over A 6-Year Period. In: Psychology and Aging. 2004 ; Vol. 19, No. 1. pp. 145-156.
@article{347991e496a44ef8a6e73f17f2511f7f,
title = "Change in Cognitive Capabilities in the Oldest Old: The Effects of Proximity to Death in Genetically Related Individuals over A 6-Year Period",
abstract = "Change in cognitive abilities was assessed over a 6-year period in a sample of monozygotic and same-sex dizygotic twin pairs (N = 507 individuals), aged 80 and older (mean age = 83.3 years: SD = 3.1), who remained nondemented over the course of the study. Latent growth models (LGMs) show that chronological age and time to death are consistent predictors of decline in measures of memory, reasoning, speed, and verbal abilities. Multivariate LGM analysis resulted in weak and often negative correlations among rates of change between individuals within twin pairs, indicating greater differential change within twin pairs than occurs on average across twin pairs. These findings highlight several challenges for estimating genetic sources of variance in the context of compromised health and mortality-related change.",
author = "Boo Johansson and Scott Hofer and Allaire, {Jason C.} and Maldonado-Molina, {Mildred M.} and Piccinin, {Andrea M.} and Stig Berg and Pedersen, {Nancy L.} and McClearn, {Gerald E.}",
year = "2004",
month = "3",
doi = "10.1037/0882-7974.19.1.145",
language = "English (US)",
volume = "19",
pages = "145--156",
journal = "Psychology and Aging",
issn = "0882-7974",
publisher = "American Psychological Association Inc.",
number = "1",

}

TY - JOUR

T1 - Change in Cognitive Capabilities in the Oldest Old

T2 - The Effects of Proximity to Death in Genetically Related Individuals over A 6-Year Period

AU - Johansson, Boo

AU - Hofer, Scott

AU - Allaire, Jason C.

AU - Maldonado-Molina, Mildred M.

AU - Piccinin, Andrea M.

AU - Berg, Stig

AU - Pedersen, Nancy L.

AU - McClearn, Gerald E.

PY - 2004/3

Y1 - 2004/3

N2 - Change in cognitive abilities was assessed over a 6-year period in a sample of monozygotic and same-sex dizygotic twin pairs (N = 507 individuals), aged 80 and older (mean age = 83.3 years: SD = 3.1), who remained nondemented over the course of the study. Latent growth models (LGMs) show that chronological age and time to death are consistent predictors of decline in measures of memory, reasoning, speed, and verbal abilities. Multivariate LGM analysis resulted in weak and often negative correlations among rates of change between individuals within twin pairs, indicating greater differential change within twin pairs than occurs on average across twin pairs. These findings highlight several challenges for estimating genetic sources of variance in the context of compromised health and mortality-related change.

AB - Change in cognitive abilities was assessed over a 6-year period in a sample of monozygotic and same-sex dizygotic twin pairs (N = 507 individuals), aged 80 and older (mean age = 83.3 years: SD = 3.1), who remained nondemented over the course of the study. Latent growth models (LGMs) show that chronological age and time to death are consistent predictors of decline in measures of memory, reasoning, speed, and verbal abilities. Multivariate LGM analysis resulted in weak and often negative correlations among rates of change between individuals within twin pairs, indicating greater differential change within twin pairs than occurs on average across twin pairs. These findings highlight several challenges for estimating genetic sources of variance in the context of compromised health and mortality-related change.

UR - http://www.scopus.com/inward/record.url?scp=1542723365&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542723365&partnerID=8YFLogxK

U2 - 10.1037/0882-7974.19.1.145

DO - 10.1037/0882-7974.19.1.145

M3 - Article

VL - 19

SP - 145

EP - 156

JO - Psychology and Aging

JF - Psychology and Aging

SN - 0882-7974

IS - 1

ER -