CEST and PARACEST MR contrast agents

Ileana Hancu, W. Thomas Dixon, Mark Woods, Elena Vinogradov, A. Dean Sherry, Robert E. Lenkinski

Research output: Contribution to journalReview article

79 Scopus citations

Abstract

In this review we describe the status of development for a new class of magnetic resonance (MR) contrast agents, based on chemical exchange saturation transfer (CEST). The mathematics and physics relevant to the description of the CEST effect in MR are presented in an appendix published in the online version only. We discuss the issues arising when translating in vitro results obtained with CEST agents to using these MR agents in in vivo model studies and in humans. Examples are given on how these agents are imaged in vivo. We summarize the status of development of these CEST agents, and speculate about the next steps that may be taken towards the demonstration of CEST MR imaging in clinical applications.

Original languageEnglish (US)
Pages (from-to)910-923
Number of pages14
JournalActa Radiologica
Volume51
Issue number8
DOIs
StatePublished - Oct 1 2010

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Keywords

  • Magnetization transfer
  • Model studies
  • Paramagnetic agents
  • Target image

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Hancu, I., Dixon, W. T., Woods, M., Vinogradov, E., Sherry, A. D., & Lenkinski, R. E. (2010). CEST and PARACEST MR contrast agents. Acta Radiologica, 51(8), 910-923. https://doi.org/10.3109/02841851.2010.502126