TY - JOUR
T1 - Central neural regulation of brown adipose tissue thermogenesis and energy expenditure
AU - Morrison, Shaun F.
AU - Madden, Christopher J.
AU - Tupone, Domenico
N1 - Funding Information:
Support of the authors’ research that contributed to this review came from National Institutes of Health grants R01NS40987 (S.F.M.), R01DK57838 (S.F.M.), and R56DK082558 (C.J.M.); an American Heart Association Scientist Development Grant and Grant-in-Aid (C.J.M.); and a Collins Medical Trust Research Grant (D.T.).
PY - 2014/5/6
Y1 - 2014/5/6
N2 - Thermogenesis, the production of heat energy, is the specific, neurally regulated, metabolic function of brown adipose tissue (BAT) and contributes to the maintenance of body temperature during cold exposure and to the elevated core temperature during several behavioral states, including wakefulness, the acute phase response (fever), and stress. BAT energy expenditure requires metabolic fuel availability and contributes to energy balance. This review summarizes the functional organization and neurochemical influences within the CNS networks governing the level of BAT sympathetic nerve activity to produce the thermoregulatory and metabolically driven alterations in BAT thermogenesis and energy expenditure that contribute to overall energy homeostasis.
AB - Thermogenesis, the production of heat energy, is the specific, neurally regulated, metabolic function of brown adipose tissue (BAT) and contributes to the maintenance of body temperature during cold exposure and to the elevated core temperature during several behavioral states, including wakefulness, the acute phase response (fever), and stress. BAT energy expenditure requires metabolic fuel availability and contributes to energy balance. This review summarizes the functional organization and neurochemical influences within the CNS networks governing the level of BAT sympathetic nerve activity to produce the thermoregulatory and metabolically driven alterations in BAT thermogenesis and energy expenditure that contribute to overall energy homeostasis.
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U2 - 10.1016/j.cmet.2014.02.007
DO - 10.1016/j.cmet.2014.02.007
M3 - Review article
C2 - 24630813
AN - SCOPUS:84900334867
SN - 1550-4131
VL - 19
SP - 741
EP - 756
JO - Cell Metabolism
JF - Cell Metabolism
IS - 5
ER -