Cellular Responses to Infections in Caenorhabditis elegans

J. Sun, Alejandro Aballay, V. Singh

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

The nematode Caenorhabditis elegans has emerged as a powerful model system to study cellular responses to microbial infections in the context of a whole animal. Like other free-living nematodes, the one millimeter long nematode C. elegans lives in the soil, where it is in contact with soil-borne microbes, including human microbial pathogens. While it lacks adaptive immunity, it has evolved mechanisms to recognize different pathogens and to respond accordingly. Caenorhabditis elegans does not seem to have conserved pattern recognition receptors (PRRs) for pathogen detection through microbe-associated molecular patterns (MAMPs), but it can recognize pathogen attack through different mechanisms, including neuronal sensation of bacterial cues and detection of disturbances of cellular homeostasis. The immune response mounted by Caenorhabditis elegans upon pathogen infection comprises evolutionarily conserved signaling pathways that result in the induction of immune effector mechanisms to combat infections. The immune response is complex and pathogen-specific.

Original languageEnglish (US)
Title of host publicationOrganizational Cell Biology
PublisherElsevier Inc.
Pages845-852
Number of pages8
Volume2
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Caenorhabditis elegans
Infection
Soil
Pattern Recognition Receptors
Adaptive Immunity
Cues
Homeostasis

Keywords

  • Caenorhabditis elegans
  • Cellular homeostasis
  • Cellular response to infection
  • Effector-triggered immunity
  • ER-stress
  • Host-pathogen interactions
  • Immune effectors
  • Innate immunity
  • Microbial pathogens
  • Unfolded protein response

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sun, J., Aballay, A., & Singh, V. (2015). Cellular Responses to Infections in Caenorhabditis elegans. In Organizational Cell Biology (Vol. 2, pp. 845-852). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-394447-4.20074-6

Cellular Responses to Infections in Caenorhabditis elegans. / Sun, J.; Aballay, Alejandro; Singh, V.

Organizational Cell Biology. Vol. 2 Elsevier Inc., 2015. p. 845-852.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sun, J, Aballay, A & Singh, V 2015, Cellular Responses to Infections in Caenorhabditis elegans. in Organizational Cell Biology. vol. 2, Elsevier Inc., pp. 845-852. https://doi.org/10.1016/B978-0-12-394447-4.20074-6
Sun J, Aballay A, Singh V. Cellular Responses to Infections in Caenorhabditis elegans. In Organizational Cell Biology. Vol. 2. Elsevier Inc. 2015. p. 845-852 https://doi.org/10.1016/B978-0-12-394447-4.20074-6
Sun, J. ; Aballay, Alejandro ; Singh, V. / Cellular Responses to Infections in Caenorhabditis elegans. Organizational Cell Biology. Vol. 2 Elsevier Inc., 2015. pp. 845-852
@inbook{7c5025375d664596b1243433a83894ca,
title = "Cellular Responses to Infections in Caenorhabditis elegans",
abstract = "The nematode Caenorhabditis elegans has emerged as a powerful model system to study cellular responses to microbial infections in the context of a whole animal. Like other free-living nematodes, the one millimeter long nematode C. elegans lives in the soil, where it is in contact with soil-borne microbes, including human microbial pathogens. While it lacks adaptive immunity, it has evolved mechanisms to recognize different pathogens and to respond accordingly. Caenorhabditis elegans does not seem to have conserved pattern recognition receptors (PRRs) for pathogen detection through microbe-associated molecular patterns (MAMPs), but it can recognize pathogen attack through different mechanisms, including neuronal sensation of bacterial cues and detection of disturbances of cellular homeostasis. The immune response mounted by Caenorhabditis elegans upon pathogen infection comprises evolutionarily conserved signaling pathways that result in the induction of immune effector mechanisms to combat infections. The immune response is complex and pathogen-specific.",
keywords = "Caenorhabditis elegans, Cellular homeostasis, Cellular response to infection, Effector-triggered immunity, ER-stress, Host-pathogen interactions, Immune effectors, Innate immunity, Microbial pathogens, Unfolded protein response",
author = "J. Sun and Alejandro Aballay and V. Singh",
year = "2015",
month = "1",
day = "1",
doi = "10.1016/B978-0-12-394447-4.20074-6",
language = "English (US)",
isbn = "9780123947963",
volume = "2",
pages = "845--852",
booktitle = "Organizational Cell Biology",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Cellular Responses to Infections in Caenorhabditis elegans

AU - Sun, J.

AU - Aballay, Alejandro

AU - Singh, V.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The nematode Caenorhabditis elegans has emerged as a powerful model system to study cellular responses to microbial infections in the context of a whole animal. Like other free-living nematodes, the one millimeter long nematode C. elegans lives in the soil, where it is in contact with soil-borne microbes, including human microbial pathogens. While it lacks adaptive immunity, it has evolved mechanisms to recognize different pathogens and to respond accordingly. Caenorhabditis elegans does not seem to have conserved pattern recognition receptors (PRRs) for pathogen detection through microbe-associated molecular patterns (MAMPs), but it can recognize pathogen attack through different mechanisms, including neuronal sensation of bacterial cues and detection of disturbances of cellular homeostasis. The immune response mounted by Caenorhabditis elegans upon pathogen infection comprises evolutionarily conserved signaling pathways that result in the induction of immune effector mechanisms to combat infections. The immune response is complex and pathogen-specific.

AB - The nematode Caenorhabditis elegans has emerged as a powerful model system to study cellular responses to microbial infections in the context of a whole animal. Like other free-living nematodes, the one millimeter long nematode C. elegans lives in the soil, where it is in contact with soil-borne microbes, including human microbial pathogens. While it lacks adaptive immunity, it has evolved mechanisms to recognize different pathogens and to respond accordingly. Caenorhabditis elegans does not seem to have conserved pattern recognition receptors (PRRs) for pathogen detection through microbe-associated molecular patterns (MAMPs), but it can recognize pathogen attack through different mechanisms, including neuronal sensation of bacterial cues and detection of disturbances of cellular homeostasis. The immune response mounted by Caenorhabditis elegans upon pathogen infection comprises evolutionarily conserved signaling pathways that result in the induction of immune effector mechanisms to combat infections. The immune response is complex and pathogen-specific.

KW - Caenorhabditis elegans

KW - Cellular homeostasis

KW - Cellular response to infection

KW - Effector-triggered immunity

KW - ER-stress

KW - Host-pathogen interactions

KW - Immune effectors

KW - Innate immunity

KW - Microbial pathogens

KW - Unfolded protein response

UR - http://www.scopus.com/inward/record.url?scp=84994855673&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994855673&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-394447-4.20074-6

DO - 10.1016/B978-0-12-394447-4.20074-6

M3 - Chapter

AN - SCOPUS:84994855673

SN - 9780123947963

VL - 2

SP - 845

EP - 852

BT - Organizational Cell Biology

PB - Elsevier Inc.

ER -