CD8+ T cell programming by cytomegalovirus vectors: applications in prophylactic and therapeutic vaccination

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

Vectors based on cytomegalovirus (CMV) represent a novel vaccine platform that maintains high frequencies of non-exhausted effector memory T cells in both CMV sero-positive and sero-negative individuals. In non-human primate models, CMV vectored vaccines provide unprecedented protection against simian immunodeficiency virus (SIV). Moreover, CMV vectors can be genetically altered to program highly diverse CD8+ T cell responses that differ in their epitope targeting including conventional, MHC-I restricted CD8+ T cells as well as unconventional CD8+ T cells restricted by MHC class II or non-polymorphic MHC-E. By modifying cytomegaloviral determinants that control unconventional T cell priming it is possible to uniquely tailor the CD8+ T cell response for each individual disease target in order to maximize prophylactic or therapeutic protection.

Original languageEnglish (US)
Pages (from-to)52-56
Number of pages5
JournalCurrent opinion in immunology
Volume47
DOIs
StatePublished - Aug 2017

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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