CD4+ T-lymphocyte depletion in human lymphoid tissue ex vivo is not induced by noninfectious human immunodeficiency virus type 1 virions

A. W. Sylwester; J. C. Grivel; W. Fitzgerald; J. L. Rossio; J. D. Lifson; L. B. Margolis

doi:10.1128/jvi.72.11.9345-9347.1998

CD4⁺ T-lymphocyte depletion in human lymphoid tissue ex vivo is not induced by noninfectious human immunodeficiency virus type 1 virions

A. W. Sylwester, J. C. Grivel, W. Fitzgerald, J. L. Rossio, J. D. Lifson, L. B. Margolis

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We tested infectious human immunodeficiency virus type 1 (HIV-1), noninfectious but conformationally authentic inactivated whole HIV-1 virions, and purified gp120 for the ability to induce depletion of CD4⁺ T cells in human lymphoid tissues ex vivo. Infectious CXCR4-tropic HIV-1, but not matched inactivated virions or gp120, mediated CD4⁺ T-cell depletion, consistent with mechanisms requiring productive infection.

Original language	English (US)
Pages (from-to)	9345-9347
Number of pages	3
Journal	Journal of virology
Volume	72
Issue number	11
DOIs	https://doi.org/10.1128/jvi.72.11.9345-9347.1998
State	Published - Nov 1998
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/jvi.72.11.9345-9347.1998

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abstract = "We tested infectious human immunodeficiency virus type 1 (HIV-1), noninfectious but conformationally authentic inactivated whole HIV-1 virions, and purified gp120 for the ability to induce depletion of CD4+ T cells in human lymphoid tissues ex vivo. Infectious CXCR4-tropic HIV-1, but not matched inactivated virions or gp120, mediated CD4+ T-cell depletion, consistent with mechanisms requiring productive infection.",

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AU - Grivel, J. C.

AU - Fitzgerald, W.

AU - Rossio, J. L.

AU - Lifson, J. D.

AU - Margolis, L. B.

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AB - We tested infectious human immunodeficiency virus type 1 (HIV-1), noninfectious but conformationally authentic inactivated whole HIV-1 virions, and purified gp120 for the ability to induce depletion of CD4+ T cells in human lymphoid tissues ex vivo. Infectious CXCR4-tropic HIV-1, but not matched inactivated virions or gp120, mediated CD4+ T-cell depletion, consistent with mechanisms requiring productive infection.

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ER -

CD4⁺ T-lymphocyte depletion in human lymphoid tissue ex vivo is not induced by noninfectious human immunodeficiency virus type 1 virions

Abstract

ASJC Scopus subject areas

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