Catechol estrogens and the control of gonadotropin and prolactin secretion in man

George R. Merriam, Doris G. Pfeiffer, Donald (Lynn) Loriaux, Mortimer B. Lipsett

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The catechol estrogens, the 2- or 4-hydroxylated metabolites of estrone and estradiol, have pharmacologic properties of both estrogens and catecholamines and are formed from estrogens in peripheral tissues and in the brain. This has led to speculation that they may mediate some of the feedback effects of estrogens upon gonadotropins and prolactin (PRL). Studies testing these hypotheses are still few and have not been conclusive. There have been reports that the catechol estrogen 2-hydroxyestrone (2-OHE1) might act as a partial estrogen antagonist, stimulating gonadotropin secretion; and that it might have dopamine-like effects, suppressing the secretion of PRL. In studies testing the chronic and acute effects of catechol estrogens on LH, FSH, and PRL in men and women, we found that they behaved as estrogens, suppressing gonadotropins when given in doses high enough to compensate for their rapid clearance and degradation. We found no evidence that they suppress PRL secretion. The weight of available evidence suggests that these effects are mediated by estrogen receptor interactions; and that the formation of catechol estrogens is not an obligatory step in the feedback effects of estrogens, although it may have a modulatory role. Plasma levels of catechol estrogens are too low for them to exert circulating neuroendocrine effects.

Original languageEnglish (US)
Pages (from-to)619-625
Number of pages7
JournalJournal of Steroid Biochemistry
Volume19
Issue number1 PART 2
DOIs
StatePublished - 1983
Externally publishedYes

Fingerprint

Catechol Estrogens
Gonadotropins
Prolactin
Estrogens
Estrogen Antagonists
Feedback
Dopamine Agents
Estrone
Testing
Metabolites
Estrogen Receptors
Catecholamines
Estradiol
Dopamine
Brain
Tissue
Plasmas
Weights and Measures
Degradation

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Catechol estrogens and the control of gonadotropin and prolactin secretion in man. / Merriam, George R.; Pfeiffer, Doris G.; Loriaux, Donald (Lynn); Lipsett, Mortimer B.

In: Journal of Steroid Biochemistry, Vol. 19, No. 1 PART 2, 1983, p. 619-625.

Research output: Contribution to journalArticle

Merriam, George R. ; Pfeiffer, Doris G. ; Loriaux, Donald (Lynn) ; Lipsett, Mortimer B. / Catechol estrogens and the control of gonadotropin and prolactin secretion in man. In: Journal of Steroid Biochemistry. 1983 ; Vol. 19, No. 1 PART 2. pp. 619-625.
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