Caspase 1 and caspase 8 in HIV infected patients with and without tuberculosis

Ajay Wanchu, A. Bhatnagar, B. Kumar, P. Bambery, S. Singh

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1 Scopus citations

Abstract

Background: Caspase 8 is involved in apoptosis mediated by Fas and p55 tumor necrosis factor receptor ligation in HIV infection. Apoptosis is partially mediated by interleukin-1 beta-converting enzyme (caspase-1). Aims: We determined apoptosis, using caspase-1 and caspase-8, among patients with HIV infection, with and without tuberculosis (TB), those with TB alone and healthy individuals. Setting and design: Cross-sectional analysis of caspase-1 and caspase-8 among patients with HIV infection, with and without TB, those with TB alone and healthy individuals. Materials and Methods: Nineteen HIV infected patients with TB (HIV+/TB+) and 20 with HIV infection without TB (HIV+/TB-) were studied. Fifteen individuals with TB alone were disease controls (HIV-/TB+) and 20 were healthy controls (HIV-/TB-). Caspases were measured by single-step ELISA using commercially available monoclonal antibodies. Statistical Analysis: Two-way ANOVA and Pearson's correlation coefficient. Results: Mean CD4 counts of HIV+/TB+ were lower than HIV+/TB- (p

Original languageEnglish (US)
Pages (from-to)98-101
Number of pages4
JournalJournal of Postgraduate Medicine
Volume50
Issue number2
Publication statusPublished - Apr 2004
Externally publishedYes

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Keywords

  • Apoptosis
  • Caspase 1
  • Caspase 8
  • HIV
  • Tuberculosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wanchu, A., Bhatnagar, A., Kumar, B., Bambery, P., & Singh, S. (2004). Caspase 1 and caspase 8 in HIV infected patients with and without tuberculosis. Journal of Postgraduate Medicine, 50(2), 98-101.