Cardiovascular applications of therapeutic ultrasound

Babak Nazer; Edward P. Gerstenfeld; Akiko Hata; Lawrence A. Crum; Thomas J. Matula

doi:10.1007/s10840-013-9845-z

Cardiovascular applications of therapeutic ultrasound

Babak Nazer, Edward P. Gerstenfeld, Akiko Hata, Lawrence A. Crum, Thomas J. Matula

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Ultrasound (US) has gained widespread use in diagnostic cardiovascular applications. At amplitudes and frequencies typical of diagnostic use, its biomechanical effects on tissue are largely negligible. However, these parameters can be altered to harness US's thermal and non-thermal effects for therapeutic indications. High-intensity focused ultrasound (HIFU) and extracorporeal shock wave therapy (ECWT) are two therapeutic US modalities which have been investigated for treating cardiac arrhythmias and ischemic heart disease, respectively. Here, we review the biomechanical effects of HIFU and ECWT, their potential therapeutic mechanisms, and pre-clinical and clinical studies demonstrating their efficacy and safety limitations. Furthermore, we discuss other potential clinical applications of therapeutic US and areas in which future research is needed.

Original language	English (US)
Pages (from-to)	287-294
Number of pages	8
Journal	Journal of Interventional Cardiac Electrophysiology
Volume	39
Issue number	3
DOIs	https://doi.org/10.1007/s10840-013-9845-z
State	Published - Apr 2014
Externally published	Yes

Keywords

Ablation
Angiogenesis
Atrial fibrillation
Ultrasound

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1007/s10840-013-9845-z

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abstract = "Ultrasound (US) has gained widespread use in diagnostic cardiovascular applications. At amplitudes and frequencies typical of diagnostic use, its biomechanical effects on tissue are largely negligible. However, these parameters can be altered to harness US's thermal and non-thermal effects for therapeutic indications. High-intensity focused ultrasound (HIFU) and extracorporeal shock wave therapy (ECWT) are two therapeutic US modalities which have been investigated for treating cardiac arrhythmias and ischemic heart disease, respectively. Here, we review the biomechanical effects of HIFU and ECWT, their potential therapeutic mechanisms, and pre-clinical and clinical studies demonstrating their efficacy and safety limitations. Furthermore, we discuss other potential clinical applications of therapeutic US and areas in which future research is needed.",

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AU - Nazer, Babak

AU - Gerstenfeld, Edward P.

AU - Hata, Akiko

AU - Crum, Lawrence A.

AU - Matula, Thomas J.

PY - 2014/4

Y1 - 2014/4

N2 - Ultrasound (US) has gained widespread use in diagnostic cardiovascular applications. At amplitudes and frequencies typical of diagnostic use, its biomechanical effects on tissue are largely negligible. However, these parameters can be altered to harness US's thermal and non-thermal effects for therapeutic indications. High-intensity focused ultrasound (HIFU) and extracorporeal shock wave therapy (ECWT) are two therapeutic US modalities which have been investigated for treating cardiac arrhythmias and ischemic heart disease, respectively. Here, we review the biomechanical effects of HIFU and ECWT, their potential therapeutic mechanisms, and pre-clinical and clinical studies demonstrating their efficacy and safety limitations. Furthermore, we discuss other potential clinical applications of therapeutic US and areas in which future research is needed.

AB - Ultrasound (US) has gained widespread use in diagnostic cardiovascular applications. At amplitudes and frequencies typical of diagnostic use, its biomechanical effects on tissue are largely negligible. However, these parameters can be altered to harness US's thermal and non-thermal effects for therapeutic indications. High-intensity focused ultrasound (HIFU) and extracorporeal shock wave therapy (ECWT) are two therapeutic US modalities which have been investigated for treating cardiac arrhythmias and ischemic heart disease, respectively. Here, we review the biomechanical effects of HIFU and ECWT, their potential therapeutic mechanisms, and pre-clinical and clinical studies demonstrating their efficacy and safety limitations. Furthermore, we discuss other potential clinical applications of therapeutic US and areas in which future research is needed.

KW - Ablation

KW - Angiogenesis

KW - Atrial fibrillation

KW - Ultrasound

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Cardiovascular applications of therapeutic ultrasound

Abstract

Keywords

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