Cardiotrophin-1 is not the sweat gland-derived differentiation factor

Beth Habecker, Diane Pennica, Story C. Landis

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Sympathetic neurons innervating sweat glands undergo a target-directed switch in neurotransmitter properties. Although the factor responsible for inducing this switch has not been identified, it appears to be a member of the neuropoietic cytokine family. Cardiotrophin-1 (CT-1), a new family member, was analyzed to determine whether it was a relevant factor. CT-1 induced choline acetyl-transferase and vasoactive intestinal peptide in cultured sympathetic neurons, and RT/PCR amplified CT-1 mRNA from footpad total RNA. The differentiation activity of CT-1 was blocked by CT-1 antiserum. The activity in sweat gland extracts and cultures was not, however, suggesting that CT-1 is not the sweat gland-derived factor.

Original languageEnglish (US)
Pages (from-to)41-44
Number of pages4
JournalNeuroReport
Volume7
Issue number1
StatePublished - Dec 29 1995
Externally publishedYes

Fingerprint

Sweat Glands
Neurons
Vasoactive Intestinal Peptide
Transferases
Choline
Neurotransmitter Agents
cardiotrophin 1
Immune Sera
RNA
Cytokines
Polymerase Chain Reaction
Messenger RNA

Keywords

  • Choline acetyltransferase
  • CNTF
  • LIF
  • Neurotransmitter regulation
  • VIP

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cardiotrophin-1 is not the sweat gland-derived differentiation factor. / Habecker, Beth; Pennica, Diane; Landis, Story C.

In: NeuroReport, Vol. 7, No. 1, 29.12.1995, p. 41-44.

Research output: Contribution to journalArticle

Habecker, B, Pennica, D & Landis, SC 1995, 'Cardiotrophin-1 is not the sweat gland-derived differentiation factor', NeuroReport, vol. 7, no. 1, pp. 41-44.
Habecker, Beth ; Pennica, Diane ; Landis, Story C. / Cardiotrophin-1 is not the sweat gland-derived differentiation factor. In: NeuroReport. 1995 ; Vol. 7, No. 1. pp. 41-44.
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