Cardiotrophin-1 is not the sweat gland-derived differentiation factor

Beth A. Habecker, Diane Pennica, Story C. Landis

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Sympathetic neurons innervating sweat glands undergo a target-directed switch in neurotransmitter properties. Although the factor responsible for inducing this switch has not been identified, it appears to be a member of the neuropoietic cytokine family. Cardiotrophin-1 (CT-1), a new family member, was analyzed to determine whether it was a relevant factor. CT-1 induced choline acetyl-transferase and vasoactive intestinal peptide in cultured sympathetic neurons, and RT/PCR amplified CT-1 mRNA from footpad total RNA. The differentiation activity of CT-1 was blocked by CT-1 antiserum. The activity in sweat gland extracts and cultures was not, however, suggesting that CT-1 is not the sweat gland-derived factor.

Original languageEnglish (US)
Pages (from-to)41-44
Number of pages4
Issue number1
StatePublished - Dec 29 1995
Externally publishedYes


  • CNTF
  • Choline acetyltransferase
  • LIF
  • Neurotransmitter regulation
  • VIP

ASJC Scopus subject areas

  • Neuroscience(all)


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