Canine distemper virus: the early blood-brain barrier lesion

Michael Axthelm, S. Krakowka

    Research output: Contribution to journalArticle

    24 Citations (Scopus)

    Abstract

    Experimental infection of gnotobiotic Beagle dogs with neurovirulent R252 canine distemper virus (CDV) resulted in hematogenous dissemination of virus to the central nervous system (CNS). Viral antigen was first detected within CNS capillary and venular endothelia and/or perivascular astrocytic foot processes and pericytes. The number of primary infection sites was evenly distributed throughout the neuraxis. Leukocytic infiltrations followed CNS endothelial cell infection by 1-2 days and were composed of both viral antigen-positive and-negative cells. These results indicate that CDV infection of the CNS is initiated by the interaction of circulating infectious virus with endothelial cells.

    Original languageEnglish (US)
    Pages (from-to)27-33
    Number of pages7
    JournalActa Neuropathologica
    Volume75
    Issue number1
    DOIs
    StatePublished - Jan 1987

    Fingerprint

    Canine Distemper Virus
    Blood-Brain Barrier
    Central Nervous System
    Viral Antigens
    Endothelial Cells
    Infection
    Germ-Free Life
    Viruses
    Pericytes
    Vascular Endothelium
    Virus Diseases
    Foot
    Dogs

    Keywords

    • Canine distemper virus
    • Endothelium
    • Morbillivirus
    • Morbillivirus pathogenesis

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Pathology and Forensic Medicine
    • Clinical Neurology

    Cite this

    Canine distemper virus : the early blood-brain barrier lesion. / Axthelm, Michael; Krakowka, S.

    In: Acta Neuropathologica, Vol. 75, No. 1, 01.1987, p. 27-33.

    Research output: Contribution to journalArticle

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