Campylobacter jejuni-associated hemolytic-uremic syndrome in a mother and daughter

B. N. Chamovitz, A. I. Hartstein, S. R. Alexander, A. B. Terry, P. Short, Ronald Katon

Research output: Contribution to journalArticle

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Abstract

A mother and daughter with Campylobacter jejuni-associated hemolytic-uremic syndrome (HUS) are discussed. The mother was hospitalized with bloody diarrhea and HUS; C jejuni was isolated from her stool. The 2-year-old daughter had been admitted five days prior to her mother with HUS following a three-day prodrome of vomiting and diarrhea. Multiple stool cultures were negative for enteric pathogens; however, cultures were not obtained until the eighth hospital day and after antibiotic therapy. Extensive investigation failed to identify another cause for the diarrheal illness or HUS in our patients. Indirect immunofluorescent antibody titers for C jejuni were 1:32 and 1:16 for the mother, and daughter, respectively. An asymptomatic 9-month-old son has C jenuni isolated from his stool and had an immunofluorescent antibody titer of 1:64. Three other family members were asymptomatic, stool-culture negative, and had immunofluorescent antibody titer ≤ 1:4. The suspectibility to develop HUS following an enteric antigenic stimulus is illustrated by the patients presented. The need for systematic investigation of all HUS cases for potential susceptibility markers, as well as an exhaustive etiology search, is emphasized.

Original languageEnglish (US)
Pages (from-to)253-256
Number of pages4
JournalPediatrics
Volume71
Issue number2
StatePublished - 1983
Externally publishedYes

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Hemolytic-Uremic Syndrome
Campylobacter jejuni
Nuclear Family
Mothers
Antibodies
Diarrhea
Vomiting
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Chamovitz, B. N., Hartstein, A. I., Alexander, S. R., Terry, A. B., Short, P., & Katon, R. (1983). Campylobacter jejuni-associated hemolytic-uremic syndrome in a mother and daughter. Pediatrics, 71(2), 253-256.

Campylobacter jejuni-associated hemolytic-uremic syndrome in a mother and daughter. / Chamovitz, B. N.; Hartstein, A. I.; Alexander, S. R.; Terry, A. B.; Short, P.; Katon, Ronald.

In: Pediatrics, Vol. 71, No. 2, 1983, p. 253-256.

Research output: Contribution to journalArticle

Chamovitz, BN, Hartstein, AI, Alexander, SR, Terry, AB, Short, P & Katon, R 1983, 'Campylobacter jejuni-associated hemolytic-uremic syndrome in a mother and daughter', Pediatrics, vol. 71, no. 2, pp. 253-256.
Chamovitz BN, Hartstein AI, Alexander SR, Terry AB, Short P, Katon R. Campylobacter jejuni-associated hemolytic-uremic syndrome in a mother and daughter. Pediatrics. 1983;71(2):253-256.
Chamovitz, B. N. ; Hartstein, A. I. ; Alexander, S. R. ; Terry, A. B. ; Short, P. ; Katon, Ronald. / Campylobacter jejuni-associated hemolytic-uremic syndrome in a mother and daughter. In: Pediatrics. 1983 ; Vol. 71, No. 2. pp. 253-256.
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