Caged lipids as tools for investigating cellular signaling

Doris Höglinger, André Nadler, Carsten Schultz

Research output: Contribution to journalReview article

47 Scopus citations

Abstract

Lipid derivatives that can be activated by light, often referred to as 'caged' lipids, are useful tools to manipulate intact cells non-invasively. Here we focus on experimental approaches that have made use of caged lipids. Apart from summarizing the recent advances and available tools in the field, we strive to highlight the experimental challenges that arise from lipid-specific biophysical properties and the abundance of an enormous diversity of distinct molecular lipid species in cells. This article is part of a Special Issue entitled Tools to study lipid functions.

Original languageEnglish (US)
Pages (from-to)1085-1096
Number of pages12
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1841
Issue number8
DOIs
StatePublished - Aug 2014

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Keywords

  • Cell entry
  • Lipid second messenger
  • Lipid signaling
  • Phosphoinositides
  • Photoactivation

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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