Cadmium exposure and neuropsychological development in school children in southwestern Spain

Miguel Rodríguez-Barranco, Marina Lacasaña, Fernando Gil, Andres Lorca, Juan Alguacil, Diane Rohlman, Beatriz González-Alzaga, Isabel Molina-Villalba, Ramón Mendoza, Clemente Aguilar-Garduño

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Abstract

This study assessed the association between cadmium exposure and neuropsychological development in children from a region with high industrial and mining activities in southwestern Spain. We conducted a cross-sectional study with 261 children aged 6-9 years between January and March 2012. Cadmium exposure was measured in urine and hair of children, and neuropsychological development was assessed with the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) and with three computerized tests from the Behavioral Assessment and Research System (BARS): Reaction Time Test (RTT), Continuous Performance Test (CPT) and Selective Attention Test (SAT). Multivariate linear regression models, adjusted for potential confounders, were used to estimate the association between neuropsychological development and cadmium exposure measured in urine and hair samples. Geometric means of urine and hair cadmium levels were 0.75. μg/g creatinine and 0.01. μg/g, respectively. We observed that doubling of levels of cadmium in urine was associated with a reduction of two points (95% CI: -3.8 to -0.4) in the Full-Scale intelligence quotient (IQ) in boys. By domains, association was statistically significant for Verbal Comprehension ( β=-2.0; p=0.04) and close to the significance level for Perceptual Reasoning ( β=-1.8; p=0.06). Among girls, only Verbal Comprehension showed suggestive associations with cadmium exposure ( β=-1.7; p=0.06). Cadmium exposure is associated with cognitive delays in boys in our region. Our results provide additional evidence of the neurotoxic effect of low-level postnatal cadmium exposure among children, and support the hypothesis of differences between sexes in the neurotoxic effect of metals on children.

Original languageEnglish (US)
Pages (from-to)66-73
Number of pages8
JournalEnvironmental Research
Volume134
DOIs
StatePublished - 2014

Fingerprint

Cadmium
Spain
cadmium
urine
hair
Urine
Hair
Association reactions
Child Development
Intelligence
Linear Models
Behavioral Research
Wechsler Scales
exposure
school
Linear regression
Sex Characteristics
Reaction Time
Creatinine
Cross-Sectional Studies

Keywords

  • Biomonitoring
  • Cadmium
  • Child
  • Gender
  • Intelligence
  • Neuropsychological development

ASJC Scopus subject areas

  • Environmental Science(all)
  • Biochemistry

Cite this

Rodríguez-Barranco, M., Lacasaña, M., Gil, F., Lorca, A., Alguacil, J., Rohlman, D., ... Aguilar-Garduño, C. (2014). Cadmium exposure and neuropsychological development in school children in southwestern Spain. Environmental Research, 134, 66-73. https://doi.org/10.1016/j.envres.2014.06.026

Cadmium exposure and neuropsychological development in school children in southwestern Spain. / Rodríguez-Barranco, Miguel; Lacasaña, Marina; Gil, Fernando; Lorca, Andres; Alguacil, Juan; Rohlman, Diane; González-Alzaga, Beatriz; Molina-Villalba, Isabel; Mendoza, Ramón; Aguilar-Garduño, Clemente.

In: Environmental Research, Vol. 134, 2014, p. 66-73.

Research output: Contribution to journalArticle

Rodríguez-Barranco, M, Lacasaña, M, Gil, F, Lorca, A, Alguacil, J, Rohlman, D, González-Alzaga, B, Molina-Villalba, I, Mendoza, R & Aguilar-Garduño, C 2014, 'Cadmium exposure and neuropsychological development in school children in southwestern Spain', Environmental Research, vol. 134, pp. 66-73. https://doi.org/10.1016/j.envres.2014.06.026
Rodríguez-Barranco, Miguel ; Lacasaña, Marina ; Gil, Fernando ; Lorca, Andres ; Alguacil, Juan ; Rohlman, Diane ; González-Alzaga, Beatriz ; Molina-Villalba, Isabel ; Mendoza, Ramón ; Aguilar-Garduño, Clemente. / Cadmium exposure and neuropsychological development in school children in southwestern Spain. In: Environmental Research. 2014 ; Vol. 134. pp. 66-73.
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