Bronchodilator Responsiveness and Reported Respiratory Symptoms in an Adult Population

Wan C. Tan, Jean Bourbeau, Paul Hernandez, Kenneth R. Chapman, Robert Cowie, J. Mark FitzGerald, Shawn Aaron, Darcy D. Marciniuk, Francois Maltais, A (Sonia) Buist, Denis E. O'Donnell, Don D. Sin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: The relationship between patient-reported symptoms and objective measures of lung function is poorly understood. Aim: To determine the association between responsiveness to bronchodilator and respiratory symptoms in random population samples. Methods: 4669 people aged 40 years and older from 8 sites in Canada completed interviewer-administered respiratory questionnaires and performed spirometry before and after administration of 200 ug of inhaled salbutamol. The effect of anthropometric variables, smoking exposure and doctor-diagnosed asthma (DDA) on bronchodilator responsiveness in forced expiratory volume in 1 second (FEV1) and in forced vital capacity (FVC) were evaluated. Multiple logistic regression was used to test for association between quintiles of increasing changes in FEV1 and in FVC after bronchodilator and several respiratory symptoms. Results: Determinants of bronchodilator change in FEV1 and FVC included age, DDA, smoking, respiratory drug use and female gender [p1 was associated with wheezing [p for trend1 or FVC are associated with different respiratory symptoms in the community. Both flow and volume bronchodilator responses are useful parameters which together can be predictive of both wheezing and breathlessness in the general population.

Original languageEnglish (US)
Article numbere58932
JournalPLoS One
Volume8
Issue number3
DOIs
StatePublished - Mar 15 2013

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bronchodilators
Bronchodilator Agents
signs and symptoms (animals and humans)
Vital Capacity
Forced Expiratory Volume
Population
Respiratory Sounds
asthma
physicians
Asthma
Smoking
Albuterol
lung function
Spirometry
Dyspnea
Canada
Logistics
questionnaires
Logistic Models
Interviews

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Tan, W. C., Bourbeau, J., Hernandez, P., Chapman, K. R., Cowie, R., FitzGerald, J. M., ... Sin, D. D. (2013). Bronchodilator Responsiveness and Reported Respiratory Symptoms in an Adult Population. PLoS One, 8(3), [e58932]. https://doi.org/10.1371/journal.pone.0058932

Bronchodilator Responsiveness and Reported Respiratory Symptoms in an Adult Population. / Tan, Wan C.; Bourbeau, Jean; Hernandez, Paul; Chapman, Kenneth R.; Cowie, Robert; FitzGerald, J. Mark; Aaron, Shawn; Marciniuk, Darcy D.; Maltais, Francois; Buist, A (Sonia); O'Donnell, Denis E.; Sin, Don D.

In: PLoS One, Vol. 8, No. 3, e58932, 15.03.2013.

Research output: Contribution to journalArticle

Tan, WC, Bourbeau, J, Hernandez, P, Chapman, KR, Cowie, R, FitzGerald, JM, Aaron, S, Marciniuk, DD, Maltais, F, Buist, AS, O'Donnell, DE & Sin, DD 2013, 'Bronchodilator Responsiveness and Reported Respiratory Symptoms in an Adult Population', PLoS One, vol. 8, no. 3, e58932. https://doi.org/10.1371/journal.pone.0058932
Tan WC, Bourbeau J, Hernandez P, Chapman KR, Cowie R, FitzGerald JM et al. Bronchodilator Responsiveness and Reported Respiratory Symptoms in an Adult Population. PLoS One. 2013 Mar 15;8(3). e58932. https://doi.org/10.1371/journal.pone.0058932
Tan, Wan C. ; Bourbeau, Jean ; Hernandez, Paul ; Chapman, Kenneth R. ; Cowie, Robert ; FitzGerald, J. Mark ; Aaron, Shawn ; Marciniuk, Darcy D. ; Maltais, Francois ; Buist, A (Sonia) ; O'Donnell, Denis E. ; Sin, Don D. / Bronchodilator Responsiveness and Reported Respiratory Symptoms in an Adult Population. In: PLoS One. 2013 ; Vol. 8, No. 3.
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