Bromocriptine holiday: Effects on dopamine receptors and turning behavior in rats

Anne M. Kenny, Michael B. Schneider, Daniel R. Baden, Ronald Pfeiffer, L. Charles Murrin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In experimental Parkinson’s disease, we studied the effects of chronic administration (30 days), withdrawal, and reinstitution of bromocriptine. Dopamine (DA) receptor supersensitivity was produced by 6-hydroxydopamine and reversed by chronic bromocriptine administration. Drug holiday reestablished sensitivity of DA receptors, but reinstitution of bromocriptine again downregulated receptors. The effects of a drug holiday on DA receptors are shortlived, and long-term clinical improvement cannot be expected. Apomorphineinduced contralateral turning produced by the lesion was unaffected by any drug regimen.

Original languageEnglish (US)
Pages (from-to)400-404
Number of pages5
JournalNeurology
Volume36
Issue number3
StatePublished - 1986
Externally publishedYes

Fingerprint

Holidays
Bromocriptine
Dopamine Receptors
Pharmaceutical Preparations
Oxidopamine
Parkinsonian Disorders
Down-Regulation
Dopamine
Drugs
Rat

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Kenny, A. M., Schneider, M. B., Baden, D. R., Pfeiffer, R., & Murrin, L. C. (1986). Bromocriptine holiday: Effects on dopamine receptors and turning behavior in rats. Neurology, 36(3), 400-404.

Bromocriptine holiday : Effects on dopamine receptors and turning behavior in rats. / Kenny, Anne M.; Schneider, Michael B.; Baden, Daniel R.; Pfeiffer, Ronald; Murrin, L. Charles.

In: Neurology, Vol. 36, No. 3, 1986, p. 400-404.

Research output: Contribution to journalArticle

Kenny, AM, Schneider, MB, Baden, DR, Pfeiffer, R & Murrin, LC 1986, 'Bromocriptine holiday: Effects on dopamine receptors and turning behavior in rats', Neurology, vol. 36, no. 3, pp. 400-404.
Kenny AM, Schneider MB, Baden DR, Pfeiffer R, Murrin LC. Bromocriptine holiday: Effects on dopamine receptors and turning behavior in rats. Neurology. 1986;36(3):400-404.
Kenny, Anne M. ; Schneider, Michael B. ; Baden, Daniel R. ; Pfeiffer, Ronald ; Murrin, L. Charles. / Bromocriptine holiday : Effects on dopamine receptors and turning behavior in rats. In: Neurology. 1986 ; Vol. 36, No. 3. pp. 400-404.
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