Broadening the growth hormone insensitivity syndrome

Ron G. Rosenfeld

Research output: Contribution to journalEditorialpeer-review

21 Scopus citations


The development of recombinant-DNA–derived human growth hormone (GH) has made it much easier to treat patients with GH deficiency.1 Unfortunately, establishing a firm diagnosis of this deficiency is frequently difficult, even if detailed records of growth are available and many biochemical tests are performed.2 Although the difficulties can be attributed at least in part to the pulsatile secretion of GH and the vagaries of GH assays, they also reflect the complex relation between GH and the insulin-like growth factor (IGF) axis. To be biologically active, GH must bind to a transmembrane receptor, the receptor must form a dimer, and an.

Original languageEnglish (US)
Pages (from-to)1145-1146
Number of pages2
JournalNew England Journal of Medicine
Issue number17
StatePublished - Oct 26 1995

ASJC Scopus subject areas

  • Medicine(all)


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