Broad cross-reactivity with marked fine specificity in the cytotoxic T cell response to flaviviruses

A. B. Hill, A. Mullbacher, C. Parrish, G. Coia, E. G. Westaway, R. V. Blanden

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Cytotoxic T (Tc) cells were generated in mice of five H-2 haplotypes against the flaviviruses Kunjin and West Nile (WNV). A panel of recombinant vaccinia viruses which between them expressed cDNA of the entire Kunjin virus genome were used to infect targets. Anti-Kunjin virus responses to determinants derived from non-structural proteins, especially NS3, NS4A and NS4B, were dominant in most mouse strains; usually only one class I major histocompatibility complex (MHC) restriction element was involved WNV-immune Tc cells showed similar but not identical patterns of antigen recognition to Kunjin virus-immune Tc cells. The extent to which WNV-immune Tc cells recognized Kunjin virus-encoded determinants varied considerably between mice of different MHC haplotypes.

Original languageEnglish (US)
Pages (from-to)1115-1123
Number of pages9
JournalJournal of General Virology
Volume73
Issue number5
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Virology

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