Broad cross-reactivity with marked fine specificity in the cytotoxic T cell response to flaviviruses

Ann Hill, A. Mullbacher, C. Parrish, G. Coia, E. G. Westaway, R. V. Blanden

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Cytotoxic T (Tc) cells were generated in mice of five H-2 haplotypes against the flaviviruses Kunjin and West Nile (WNV). A panel of recombinant vaccinia viruses which between them expressed cDNA of the entire Kunjin virus genome were used to infect targets. Anti-Kunjin virus responses to determinants derived from non-structural proteins, especially NS3, NS4A and NS4B, were dominant in most mouse strains; usually only one class I major histocompatibility complex (MHC) restriction element was involved WNV-immune Tc cells showed similar but not identical patterns of antigen recognition to Kunjin virus-immune Tc cells. The extent to which WNV-immune Tc cells recognized Kunjin virus-encoded determinants varied considerably between mice of different MHC haplotypes.

Original languageEnglish (US)
Pages (from-to)1115-1123
Number of pages9
JournalJournal of General Virology
Volume73
Issue number5
StatePublished - 1992
Externally publishedYes

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Flavivirus
West Nile virus
T-Lymphocytes
Major Histocompatibility Complex
Haplotypes
Vaccinia virus
Complementary DNA
Genome
Antigens
Proteins

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Hill, A., Mullbacher, A., Parrish, C., Coia, G., Westaway, E. G., & Blanden, R. V. (1992). Broad cross-reactivity with marked fine specificity in the cytotoxic T cell response to flaviviruses. Journal of General Virology, 73(5), 1115-1123.

Broad cross-reactivity with marked fine specificity in the cytotoxic T cell response to flaviviruses. / Hill, Ann; Mullbacher, A.; Parrish, C.; Coia, G.; Westaway, E. G.; Blanden, R. V.

In: Journal of General Virology, Vol. 73, No. 5, 1992, p. 1115-1123.

Research output: Contribution to journalArticle

Hill, A, Mullbacher, A, Parrish, C, Coia, G, Westaway, EG & Blanden, RV 1992, 'Broad cross-reactivity with marked fine specificity in the cytotoxic T cell response to flaviviruses', Journal of General Virology, vol. 73, no. 5, pp. 1115-1123.
Hill, Ann ; Mullbacher, A. ; Parrish, C. ; Coia, G. ; Westaway, E. G. ; Blanden, R. V. / Broad cross-reactivity with marked fine specificity in the cytotoxic T cell response to flaviviruses. In: Journal of General Virology. 1992 ; Vol. 73, No. 5. pp. 1115-1123.
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