Broad cross-reactivity with marked fine specificity in the cytotoxic T cell response to flaviviruses

A. B. Hill; A. Mullbacher; C. Parrish; G. Coia; E. G. Westaway; R. V. Blanden

doi:10.1099/0022-1317-73-5-1115

Broad cross-reactivity with marked fine specificity in the cytotoxic T cell response to flaviviruses

A. B. Hill, A. Mullbacher, C. Parrish, G. Coia, E. G. Westaway, R. V. Blanden

Molecular Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Cytotoxic T (Tc) cells were generated in mice of five H-2 haplotypes against the flaviviruses Kunjin and West Nile (WNV). A panel of recombinant vaccinia viruses which between them expressed cDNA of the entire Kunjin virus genome were used to infect targets. Anti-Kunjin virus responses to determinants derived from non-structural proteins, especially NS3, NS4A and NS4B, were dominant in most mouse strains; usually only one class I major histocompatibility complex (MHC) restriction element was involved WNV-immune Tc cells showed similar but not identical patterns of antigen recognition to Kunjin virus-immune Tc cells. The extent to which WNV-immune Tc cells recognized Kunjin virus-encoded determinants varied considerably between mice of different MHC haplotypes.

Original language	English (US)
Pages (from-to)	1115-1123
Number of pages	9
Journal	Journal of General Virology
Volume	73
Issue number	5
DOIs	https://doi.org/10.1099/0022-1317-73-5-1115
State	Published - 1992

ASJC Scopus subject areas

Virology

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10.1099/0022-1317-73-5-1115

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title = "Broad cross-reactivity with marked fine specificity in the cytotoxic T cell response to flaviviruses",

abstract = "Cytotoxic T (Tc) cells were generated in mice of five H-2 haplotypes against the flaviviruses Kunjin and West Nile (WNV). A panel of recombinant vaccinia viruses which between them expressed cDNA of the entire Kunjin virus genome were used to infect targets. Anti-Kunjin virus responses to determinants derived from non-structural proteins, especially NS3, NS4A and NS4B, were dominant in most mouse strains; usually only one class I major histocompatibility complex (MHC) restriction element was involved WNV-immune Tc cells showed similar but not identical patterns of antigen recognition to Kunjin virus-immune Tc cells. The extent to which WNV-immune Tc cells recognized Kunjin virus-encoded determinants varied considerably between mice of different MHC haplotypes.",

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T1 - Broad cross-reactivity with marked fine specificity in the cytotoxic T cell response to flaviviruses

AU - Hill, A. B.

AU - Mullbacher, A.

AU - Parrish, C.

AU - Coia, G.

AU - Westaway, E. G.

AU - Blanden, R. V.

PY - 1992

Y1 - 1992

N2 - Cytotoxic T (Tc) cells were generated in mice of five H-2 haplotypes against the flaviviruses Kunjin and West Nile (WNV). A panel of recombinant vaccinia viruses which between them expressed cDNA of the entire Kunjin virus genome were used to infect targets. Anti-Kunjin virus responses to determinants derived from non-structural proteins, especially NS3, NS4A and NS4B, were dominant in most mouse strains; usually only one class I major histocompatibility complex (MHC) restriction element was involved WNV-immune Tc cells showed similar but not identical patterns of antigen recognition to Kunjin virus-immune Tc cells. The extent to which WNV-immune Tc cells recognized Kunjin virus-encoded determinants varied considerably between mice of different MHC haplotypes.

AB - Cytotoxic T (Tc) cells were generated in mice of five H-2 haplotypes against the flaviviruses Kunjin and West Nile (WNV). A panel of recombinant vaccinia viruses which between them expressed cDNA of the entire Kunjin virus genome were used to infect targets. Anti-Kunjin virus responses to determinants derived from non-structural proteins, especially NS3, NS4A and NS4B, were dominant in most mouse strains; usually only one class I major histocompatibility complex (MHC) restriction element was involved WNV-immune Tc cells showed similar but not identical patterns of antigen recognition to Kunjin virus-immune Tc cells. The extent to which WNV-immune Tc cells recognized Kunjin virus-encoded determinants varied considerably between mice of different MHC haplotypes.

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Broad cross-reactivity with marked fine specificity in the cytotoxic T cell response to flaviviruses

Abstract

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