Bradykinin causes a prolonged increase in skin microvascular permeability

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Bradykinin is an endogenous inflammatory mediator, and its mechanism of action is incompletely understood. It is controversial whether bradykinin causes a sustained increase in microvascular permeability, or has only a transient effect. In anesthetized dogs intraarterial infusion of bradykinin (0.14 to 0.54 μg/kg/min) produced an immediate increase in flow of protein-rich, hindpaw lymph. After 210 min of bradykinin infusion lymph flow was threefold greater than baseline, lymph protein concentration remained doubled, and in a dose-related fashion bradykinin produced a sustained increase in lymph protein flux. Lymph flow was then further increased with venous hypertension, and after 4 hr lymph protein flux remained greater from the bradykinin paws than from the control paws. This sustained increase in protein flux indicates that bradykinin produces an increase in permeability at the microvascular membrane by a mechanism that is different from how the initial increase in permeability was produced.

Original languageEnglish (US)
Pages (from-to)540-549
Number of pages10
JournalJournal of Surgical Research
Volume40
Issue number6
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Capillary Permeability
Bradykinin
Lymph
Skin
Proteins
Intra Arterial Infusions
Permeability
Dogs
Hypertension
Membranes

ASJC Scopus subject areas

  • Surgery

Cite this

Bradykinin causes a prolonged increase in skin microvascular permeability. / Mullins, Richard.

In: Journal of Surgical Research, Vol. 40, No. 6, 1986, p. 540-549.

Research output: Contribution to journalArticle

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