Abstract
Botulinum toxin (BT) is a neurotoxin that paralyzes muscles by inhibiting release of acetylcholine from presynaptic vesicles at the neuromuscular junction. In people with multiple sclerosis (MS), clinical experience and research studies show that local injection of minute quantities of BT can temporarily control skeletal muscle spasticity, bladder detrusor hyperreflexia, and tremor. Specifically, BT injections have been shown to reduce muscle tone and improve passive function, and possibly improve active function, in patients with spasticity. Injection of BT into the bladder wall is a uniquely effective, safe, and durable treatment in patients with neurogenic detrusor hyperreflexia due to MS who have insufficient response or who do not tolerate oral antimuscarinic medications. This procedure has markedly reduced the need for indwelling catheters and bladder surgery. In addition, a recent study suggests BT may be effective for select patients with MS-associated upper extremity tremor. Appropriate use of BT can improve quality of life for many patients with MS.
| Original language | English (US) |
|---|---|
| Article number | 463 |
| Journal | Current Neurology and Neuroscience Reports |
| Volume | 14 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- Botulinum toxin
- Incontinence
- Multiple sclerosis
- Spasticity
- Tremor
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
- Medicine(all)
Cite this
Botulinum toxin for symptomatic therapy in multiple sclerosis. / Cameron, Michelle; Bethoux, Francois; Davis, Nina; Frederick, Meredith.
In: Current Neurology and Neuroscience Reports, Vol. 14, No. 8, 463, 2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Botulinum toxin for symptomatic therapy in multiple sclerosis
AU - Cameron, Michelle
AU - Bethoux, Francois
AU - Davis, Nina
AU - Frederick, Meredith
PY - 2014
Y1 - 2014
N2 - Botulinum toxin (BT) is a neurotoxin that paralyzes muscles by inhibiting release of acetylcholine from presynaptic vesicles at the neuromuscular junction. In people with multiple sclerosis (MS), clinical experience and research studies show that local injection of minute quantities of BT can temporarily control skeletal muscle spasticity, bladder detrusor hyperreflexia, and tremor. Specifically, BT injections have been shown to reduce muscle tone and improve passive function, and possibly improve active function, in patients with spasticity. Injection of BT into the bladder wall is a uniquely effective, safe, and durable treatment in patients with neurogenic detrusor hyperreflexia due to MS who have insufficient response or who do not tolerate oral antimuscarinic medications. This procedure has markedly reduced the need for indwelling catheters and bladder surgery. In addition, a recent study suggests BT may be effective for select patients with MS-associated upper extremity tremor. Appropriate use of BT can improve quality of life for many patients with MS.
AB - Botulinum toxin (BT) is a neurotoxin that paralyzes muscles by inhibiting release of acetylcholine from presynaptic vesicles at the neuromuscular junction. In people with multiple sclerosis (MS), clinical experience and research studies show that local injection of minute quantities of BT can temporarily control skeletal muscle spasticity, bladder detrusor hyperreflexia, and tremor. Specifically, BT injections have been shown to reduce muscle tone and improve passive function, and possibly improve active function, in patients with spasticity. Injection of BT into the bladder wall is a uniquely effective, safe, and durable treatment in patients with neurogenic detrusor hyperreflexia due to MS who have insufficient response or who do not tolerate oral antimuscarinic medications. This procedure has markedly reduced the need for indwelling catheters and bladder surgery. In addition, a recent study suggests BT may be effective for select patients with MS-associated upper extremity tremor. Appropriate use of BT can improve quality of life for many patients with MS.
KW - Botulinum toxin
KW - Incontinence
KW - Multiple sclerosis
KW - Spasticity
KW - Tremor
UR - http://www.scopus.com/inward/record.url?scp=84902736086&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902736086&partnerID=8YFLogxK
U2 - 10.1007/s11910-014-0463-7
DO - 10.1007/s11910-014-0463-7
M3 - Article
VL - 14
JO - Current Neurology and Neuroscience Reports
JF - Current Neurology and Neuroscience Reports
SN - 1528-4042
IS - 8
M1 - 463
ER -