Botulinum toxin for symptomatic therapy in multiple sclerosis

Michelle Cameron, Francois Bethoux, Nina Davis, Meredith Frederick

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Botulinum toxin (BT) is a neurotoxin that paralyzes muscles by inhibiting release of acetylcholine from presynaptic vesicles at the neuromuscular junction. In people with multiple sclerosis (MS), clinical experience and research studies show that local injection of minute quantities of BT can temporarily control skeletal muscle spasticity, bladder detrusor hyperreflexia, and tremor. Specifically, BT injections have been shown to reduce muscle tone and improve passive function, and possibly improve active function, in patients with spasticity. Injection of BT into the bladder wall is a uniquely effective, safe, and durable treatment in patients with neurogenic detrusor hyperreflexia due to MS who have insufficient response or who do not tolerate oral antimuscarinic medications. This procedure has markedly reduced the need for indwelling catheters and bladder surgery. In addition, a recent study suggests BT may be effective for select patients with MS-associated upper extremity tremor. Appropriate use of BT can improve quality of life for many patients with MS.

Original languageEnglish (US)
Article number463
JournalCurrent Neurology and Neuroscience Reports
Volume14
Issue number8
DOIs
StatePublished - 2014

Fingerprint

Botulinum Toxins
Multiple Sclerosis
Abnormal Reflexes
Urinary Bladder
Tremor
Injections
Therapeutics
Muscles
Muscarinic Antagonists
Indwelling Catheters
Muscle Spasticity
Neuromuscular Junction
Neurotoxins
Upper Extremity
Paralysis
Acetylcholine
Skeletal Muscle
Quality of Life
Research

Keywords

  • Botulinum toxin
  • Incontinence
  • Multiple sclerosis
  • Spasticity
  • Tremor

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Medicine(all)

Cite this

Botulinum toxin for symptomatic therapy in multiple sclerosis. / Cameron, Michelle; Bethoux, Francois; Davis, Nina; Frederick, Meredith.

In: Current Neurology and Neuroscience Reports, Vol. 14, No. 8, 463, 2014.

Research output: Contribution to journalArticle

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