Bone Marrow-Derived Hepatocytes

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Several independent reports have demonstrated that bone marrow cells can give rise to different hepatic epithelial cells types, including oval cells, hepatocytes and duct epithelium. These observations have resulted in the hypothesis that bone marrow resident stem cells, specifically haematopoietic stem cells, are an important source for liver epithelial cell replacement, particularly during chronic injury. However, the bulk of published data on the role of bone marrow stem cells in liver damage suggest that they do not play a significant physiological role in replacement of epithelial cells in any known form of hepatic injury. Fully functional bone marrow-derived hepatocytes indeed exist, but are extremely rare and are generated by cell fusion, not stem cell differentiation.

Original languageEnglish (US)
Title of host publicationStem Cells: Nuclear Reprogramming and Therapeutic Applications
PublisherJohn Wiley and Sons Ltd.
Pages20-27
Number of pages8
Volume265
ISBN (Electronic)9780470091456
ISBN (Print)0470091436, 9780470091432
DOIs
StatePublished - Oct 7 2008

Keywords

  • Bone marrow resident stem cells
  • Bone marrow transplantation (BMT) patients
  • Bone marrow-derived hepatocyte
  • Cell fusion
  • Fluorescent in situ hybridization (FISH)
  • Granulocyte/macrophage progenitors (GMPs)
  • Haematopoietic stem cell (HSC) and KLTS cell
  • Haematopoietic system
  • Hepatic oval cells
  • Specialized endodermal stem cell

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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