Blood Omega-3 and Trans Fatty Acids in Middle-Aged Acute Coronary Syndrome Patients

William Harris, Kimberly J. Reid, Scott A. Sands, John A. Spertus

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

We tested the hypothesis that lower blood omega-3 (ω-3) fatty acids (FAs) and/or higher trans FAs are associated with the risk of an acute coronary syndrome (ACS). Higher levels of ω-3 FA have been associated with decreased risk of sudden cardiac death. However, their association with ACS risk is unclear. Although higher self-reported intakes of trans FAs have been linked to increased coronary risk, the association between blood levels of trans FA and ACS risk is also unknown. We analyzed the FA composition of whole blood from 94 subjects with ACS and 94 age-, gender-, and race-matched controls. Omega-3 and trans FA associations with ACS were assessed using multivariable models after adjusting for smoking status, alcohol use, diabetes, body mass index, serum lipids, and history of myocardial infarction or revascularization. Subjects' mean age was 47 years, 54% were men, and 80% were Caucasian. Whole blood long-chain ω-3 FA (eicosapentaenoic acid [EPA] plus docosahexaenoic acid [DHA]) content was 29% lower in patients than in controls (1.7 ± 0.9% vs 2.4 ± 1.4%, p

Original languageEnglish (US)
Pages (from-to)154-158
Number of pages5
JournalAmerican Journal of Cardiology
Volume99
Issue number2
DOIs
StatePublished - Jan 15 2007
Externally publishedYes

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Trans Fatty Acids
Omega-3 Fatty Acids
Acute Coronary Syndrome
Fatty Acids
Myocardial Revascularization
Eicosapentaenoic Acid
Docosahexaenoic Acids
Sudden Cardiac Death
Body Mass Index
Smoking
Myocardial Infarction
Alcohols
Lipids
Serum

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Blood Omega-3 and Trans Fatty Acids in Middle-Aged Acute Coronary Syndrome Patients. / Harris, William; Reid, Kimberly J.; Sands, Scott A.; Spertus, John A.

In: American Journal of Cardiology, Vol. 99, No. 2, 15.01.2007, p. 154-158.

Research output: Contribution to journalArticle

Harris, William ; Reid, Kimberly J. ; Sands, Scott A. ; Spertus, John A. / Blood Omega-3 and Trans Fatty Acids in Middle-Aged Acute Coronary Syndrome Patients. In: American Journal of Cardiology. 2007 ; Vol. 99, No. 2. pp. 154-158.
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