Blast Exposure Impairs Sensory Gating

Evidence from Measures of Acoustic Startle and Auditory Event-Related Potentials

Melissa A. Papesh, Jonathan E. Elliott, Megan L. Callahan, Daniel Storzbach, Miranda Lim, Frederick Gallun

Research output: Contribution to journalArticle

Abstract

Many military service members and veterans who have been exposed to high-intensity blast waves experience traumatic brain injury (TBI), resulting in chronic auditory deficits despite normal hearing sensitivity. The current study sought to examine the neurological cause of this chronic dysfunction by testing the hypothesis that blast exposure leads to impaired filtering of sensory information at brainstem and early cortical levels. Groups of blast-exposed and non-blast-exposed participants completed self-report measures of auditory and neurobehavioral status, auditory perceptual tasks involving degraded and competing speech stimuli, and physiological measures of sensory gating, including pre-pulse inhibition and habituation of the acoustic startle reflex and electrophysiological assessment of a paired-click sensory gating paradigm. Blast-exposed participants showed significantly reduced habituation to acoustic startle stimuli and impaired filtering of redundant sensory information at the level the auditory cortex. Multiple linear regression analyses revealed that poorer sensory gating at the cortical level was primarily influenced by a diagnosis of TBI, whereas reduced habituation was primarily influenced by a diagnosis of post-traumatic stress disorder. A statistical model was created including cortical sensory gating and habituation to acoustic startle, which strongly predicted performance on a degraded speech task. These results support the hypothesis that blast exposure impairs central auditory processing via impairment of neural mechanisms underlying habituation and sensory gating.

Original languageEnglish (US)
Pages (from-to)702-712
Number of pages11
JournalJournal of Neurotrauma
Volume36
Issue number5
DOIs
StatePublished - Mar 1 2019

Fingerprint

Sensory Gating
Evoked Potentials
Acoustics
Startle Reflex
Auditory Cortex
Statistical Models
Veterans
Post-Traumatic Stress Disorders
Self Report
Hearing
Brain Stem
Linear Models
Regression Analysis

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Blast Exposure Impairs Sensory Gating : Evidence from Measures of Acoustic Startle and Auditory Event-Related Potentials. / Papesh, Melissa A.; Elliott, Jonathan E.; Callahan, Megan L.; Storzbach, Daniel; Lim, Miranda; Gallun, Frederick.

In: Journal of Neurotrauma, Vol. 36, No. 5, 01.03.2019, p. 702-712.

Research output: Contribution to journalArticle

Papesh, Melissa A. ; Elliott, Jonathan E. ; Callahan, Megan L. ; Storzbach, Daniel ; Lim, Miranda ; Gallun, Frederick. / Blast Exposure Impairs Sensory Gating : Evidence from Measures of Acoustic Startle and Auditory Event-Related Potentials. In: Journal of Neurotrauma. 2019 ; Vol. 36, No. 5. pp. 702-712.
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