BIOSYNTHETIC METHIONYL HUMAN GROWTH HORMONE IS BIOLOGICALLY ACTIVE IN ADULT MAN

R. L. Hintz, D. M. Wilson, J. Finno, Ronald (Ron) Rosenfeld, A. Bennett, B. Mcclellan, R. Swift

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The acute effects of synthetic methionyl human growth hormone produced by recombinant DNA technology were compared with those of pituitary human growth hormone in 22 healthy male volunteers. Both caused increases in somatomedin and triglycerides and decreases in blood urea nitrogen and cholesterol. By all indices measured, synthetic methionyl human growth hormone was equipotent with pituitary human growth hormone. The ability to make biologically active synthetic human growth, hormone creates an essentially unlimited supply of growth hormone for the treatment of hypopituitarism and for the study of additional therapeutic indications.

Original languageEnglish (US)
Pages (from-to)1276-1279
Number of pages4
JournalThe Lancet
Volume319
Issue number8284
DOIs
StatePublished - Jun 5 1982
Externally publishedYes

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Human Growth Hormone
Growth Hormone
Hypopituitarism
Recombinant DNA
Blood Urea Nitrogen
Somatomedins
Healthy Volunteers
Triglycerides
Cholesterol
Technology
Therapeutics
somatrem

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hintz, R. L., Wilson, D. M., Finno, J., Rosenfeld, R. R., Bennett, A., Mcclellan, B., & Swift, R. (1982). BIOSYNTHETIC METHIONYL HUMAN GROWTH HORMONE IS BIOLOGICALLY ACTIVE IN ADULT MAN. The Lancet, 319(8284), 1276-1279. https://doi.org/10.1016/S0140-6736(82)92843-4

BIOSYNTHETIC METHIONYL HUMAN GROWTH HORMONE IS BIOLOGICALLY ACTIVE IN ADULT MAN. / Hintz, R. L.; Wilson, D. M.; Finno, J.; Rosenfeld, Ronald (Ron); Bennett, A.; Mcclellan, B.; Swift, R.

In: The Lancet, Vol. 319, No. 8284, 05.06.1982, p. 1276-1279.

Research output: Contribution to journalArticle

Hintz, RL, Wilson, DM, Finno, J, Rosenfeld, RR, Bennett, A, Mcclellan, B & Swift, R 1982, 'BIOSYNTHETIC METHIONYL HUMAN GROWTH HORMONE IS BIOLOGICALLY ACTIVE IN ADULT MAN', The Lancet, vol. 319, no. 8284, pp. 1276-1279. https://doi.org/10.1016/S0140-6736(82)92843-4
Hintz RL, Wilson DM, Finno J, Rosenfeld RR, Bennett A, Mcclellan B et al. BIOSYNTHETIC METHIONYL HUMAN GROWTH HORMONE IS BIOLOGICALLY ACTIVE IN ADULT MAN. The Lancet. 1982 Jun 5;319(8284):1276-1279. https://doi.org/10.1016/S0140-6736(82)92843-4
Hintz, R. L. ; Wilson, D. M. ; Finno, J. ; Rosenfeld, Ronald (Ron) ; Bennett, A. ; Mcclellan, B. ; Swift, R. / BIOSYNTHETIC METHIONYL HUMAN GROWTH HORMONE IS BIOLOGICALLY ACTIVE IN ADULT MAN. In: The Lancet. 1982 ; Vol. 319, No. 8284. pp. 1276-1279.
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