Biological laser action

Lihong Wang; Da Liu; Nancy He; Steven L. Jacques; Sharon L. Thomsen

doi:10.1364/AO.35.001775

Biological laser action

Lihong Wang, Da Liu, Nancy He, Steven L. Jacques, Sharon L. Thomsen

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The narrowing of the spectral linewidth and the increasing of the peak intensity characteristic of laser action were observed in emission spectra of dye-infused biological tissues. The tissue was infused with a solution of Rhodamine 640 perchlorate in ethanol and then excited with frequency–doubled Q–switched Nd:YAG laser pulses. The dependence of emission linewidth on the excitation radiant exposure and dye concentration was investigated. Laser action was also observed in biologically compatible fluorescein sodium dye dissolved in phosphate–buffered saline mixed with scattering polystyrene spheres. The sharp spectral peaks of laser action in tissues may find applications in the detection of superficial disease.

Original language	English (US)
Pages (from-to)	1775-1779
Number of pages	5
Journal	Applied Optics
Volume	35
Issue number	10
DOIs	https://doi.org/10.1364/AO.35.001775
State	Published - Apr 1 1996
Externally published	Yes

Keywords

Amplification of spontaneous emission
Fluorescence
Laser action
Tissue optics
Turbid media

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Engineering (miscellaneous)
Electrical and Electronic Engineering

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10.1364/AO.35.001775

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title = "Biological laser action",

abstract = "The narrowing of the spectral linewidth and the increasing of the peak intensity characteristic of laser action were observed in emission spectra of dye-infused biological tissues. The tissue was infused with a solution of Rhodamine 640 perchlorate in ethanol and then excited with frequency–doubled Q–switched Nd:YAG laser pulses. The dependence of emission linewidth on the excitation radiant exposure and dye concentration was investigated. Laser action was also observed in biologically compatible fluorescein sodium dye dissolved in phosphate–buffered saline mixed with scattering polystyrene spheres. The sharp spectral peaks of laser action in tissues may find applications in the detection of superficial disease.",

keywords = "Amplification of spontaneous emission, Fluorescence, Laser action, Tissue optics, Turbid media",

author = "Lihong Wang and Da Liu and Nancy He and Jacques, {Steven L.} and Thomsen, {Sharon L.}",

year = "1996",

month = apr,

day = "1",

doi = "10.1364/AO.35.001775",

language = "English (US)",

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journal = "Applied Optics",

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TY - JOUR

T1 - Biological laser action

AU - Wang, Lihong

AU - Liu, Da

AU - He, Nancy

AU - Jacques, Steven L.

AU - Thomsen, Sharon L.

PY - 1996/4/1

Y1 - 1996/4/1

N2 - The narrowing of the spectral linewidth and the increasing of the peak intensity characteristic of laser action were observed in emission spectra of dye-infused biological tissues. The tissue was infused with a solution of Rhodamine 640 perchlorate in ethanol and then excited with frequency–doubled Q–switched Nd:YAG laser pulses. The dependence of emission linewidth on the excitation radiant exposure and dye concentration was investigated. Laser action was also observed in biologically compatible fluorescein sodium dye dissolved in phosphate–buffered saline mixed with scattering polystyrene spheres. The sharp spectral peaks of laser action in tissues may find applications in the detection of superficial disease.

AB - The narrowing of the spectral linewidth and the increasing of the peak intensity characteristic of laser action were observed in emission spectra of dye-infused biological tissues. The tissue was infused with a solution of Rhodamine 640 perchlorate in ethanol and then excited with frequency–doubled Q–switched Nd:YAG laser pulses. The dependence of emission linewidth on the excitation radiant exposure and dye concentration was investigated. Laser action was also observed in biologically compatible fluorescein sodium dye dissolved in phosphate–buffered saline mixed with scattering polystyrene spheres. The sharp spectral peaks of laser action in tissues may find applications in the detection of superficial disease.

KW - Amplification of spontaneous emission

KW - Fluorescence

KW - Laser action

KW - Tissue optics

KW - Turbid media

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DO - 10.1364/AO.35.001775

M3 - Article

C2 - 21085301

AN - SCOPUS:0010542714

SN - 1559-128X

VL - 35

SP - 1775

EP - 1779

JO - Applied Optics

JF - Applied Optics

IS - 10

ER -

Biological laser action

Abstract

Keywords

ASJC Scopus subject areas

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