Biogenesis and degradation of gap junctions

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)

Abstract

The dynamic regulation of gap junction biogenesis and degradation is a key element in the control of intercellular communication. This regulation starts in the endoplasmic reticulum, in which a large fraction of newly synthesized connexin molecules can be degraded. Multisubunit assembly of endogenously expressed connexins is first detected in the trans-Golgi network, as opposed to the endoplasmic reticulum wherein most other integral membrane proteins oligomerize. Gap junction plaques grow, at least in part, by lateral diffusion of plasma membrane connexin hemichannels to the periphery of the plaques. Connexins have a half-life of a few hours, being turned over within the endoplasmic reticulum by the ubiquitin/proteasome system and after transport to the cell surface via the lysosome. Although some aspects of gap junction biogenesis and degradation are relatively well understood, several intriguing unanswered questions remain.

Original languageEnglish (US)
Title of host publicationConnexins: A Guide
PublisherHumana Press Inc.
Pages225-240
Number of pages16
ISBN (Print)9781597454896, 9781934115466
DOIs
StatePublished - 2009

Fingerprint

Connexins
Gap Junctions
Endoplasmic Reticulum
Degradation
trans-Golgi Network
Proteasome Endopeptidase Complex
Cell membranes
Ubiquitin
Lysosomes
Half-Life
Membrane Proteins
Cell Membrane
Molecules
Communication

Keywords

  • Assembly
  • Cx26
  • Cx32
  • Cx43
  • Cx46
  • Degradation
  • Endoplasmic reticulum
  • ER-associated degradation
  • Golgi
  • Heat-shock
  • Hemichannel
  • Lysosome
  • Proteasome
  • Trans-Golgi network
  • Ubiquitin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Musil, L. (2009). Biogenesis and degradation of gap junctions. In Connexins: A Guide (pp. 225-240). Humana Press Inc.. https://doi.org/10.1007/978-1-59745-489-6_9

Biogenesis and degradation of gap junctions. / Musil, Linda.

Connexins: A Guide. Humana Press Inc., 2009. p. 225-240.

Research output: Chapter in Book/Report/Conference proceedingChapter

Musil, L 2009, Biogenesis and degradation of gap junctions. in Connexins: A Guide. Humana Press Inc., pp. 225-240. https://doi.org/10.1007/978-1-59745-489-6_9
Musil L. Biogenesis and degradation of gap junctions. In Connexins: A Guide. Humana Press Inc. 2009. p. 225-240 https://doi.org/10.1007/978-1-59745-489-6_9
Musil, Linda. / Biogenesis and degradation of gap junctions. Connexins: A Guide. Humana Press Inc., 2009. pp. 225-240
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