Biogenesis and degradation of gap junctions

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Abstract

The dynamic regulation of gap junction biogenesis and degradation is a key element in the control of intercellular communication. This regulation starts in the endoplasmic reticulum, in which a large fraction of newly synthesized connexin molecules can be degraded. Multisubunit assembly of endogenously expressed connexins is first detected in the trans-Golgi network, as opposed to the endoplasmic reticulum wherein most other integral membrane proteins oligomerize. Gap junction plaques grow, at least in part, by lateral diffusion of plasma membrane connexin hemichannels to the periphery of the plaques. Connexins have a half-life of a few hours, being turned over within the endoplasmic reticulum by the ubiquitin/proteasome system and after transport to the cell surface via the lysosome. Although some aspects of gap junction biogenesis and degradation are relatively well understood, several intriguing unanswered questions remain.

Original languageEnglish (US)
Title of host publicationConnexins
Subtitle of host publicationA Guide
PublisherHumana Press Inc.
Pages225-240
Number of pages16
ISBN (Electronic)9781597454896
ISBN (Print)9781934115466
DOIs
StatePublished - Jan 1 2009

Keywords

  • Assembly
  • Cx26
  • Cx32
  • Cx43
  • Cx46
  • Degradation
  • ER-associated degradation
  • Endoplasmic reticulum
  • Golgi
  • Heat-shock
  • Hemichannel
  • Lysosome
  • Proteasome
  • Trans-Golgi network
  • Ubiquitin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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