Bioactive androgens and glucuronidated androgen metabolites are associated with subcutaneous and ectopic skeletal muscle adiposity among older black men

Iva Miljkovic, Jane A. Cauley, Amy S. Dressen, Christopher L. Gordon, Bret H. Goodpaster, Lewis H. Kuller, Clareann H. Bunker, Alan L. Patrick, Victor W. Wheeler, Eric Orwoll, Joseph M. Zmuda

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Aging is associated with declining serum levels of androgenic hormones and with increased skeletal muscle fat infiltration, an emerging risk factor for type 2 diabetes mellitus (T2DM). Androgens regulate fat mass and glucose homeostasis, but the effect of androgenic hormones on skeletal muscle fat infiltration is largely unknown. Thus, the aim of the current study was to examine the association of serum androgens and their precursors and metabolites with skeletal muscle fat infiltration and T2DM in a black male population group at high risk of T2DM. Serum androgens, estrogens, and androgen precursors and metabolites were measured using mass spectrometry; and calf skeletal muscle fat distribution (subcutaneous and intermuscular fat; skeletal muscle density) was measured using quantitative computed tomography in 472 Afro-Caribbean men 65 years and older. Bioactive androgens, testosterone, free testosterone, and dihydrotestosterone were associated with less skeletal muscle fat infiltration (r = -0.14 to -0.18, P

Original languageEnglish (US)
Pages (from-to)1178-1185
Number of pages8
JournalMetabolism: Clinical and Experimental
Volume60
Issue number8
DOIs
StatePublished - Aug 2011

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Adiposity
Androgens
Skeletal Muscle
Fats
Type 2 Diabetes Mellitus
Testosterone
Serum
Hormones
Dihydrotestosterone
Subcutaneous Fat
Population Groups
Mass Spectrometry
Estrogens
Homeostasis
Tomography
Glucose

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Bioactive androgens and glucuronidated androgen metabolites are associated with subcutaneous and ectopic skeletal muscle adiposity among older black men. / Miljkovic, Iva; Cauley, Jane A.; Dressen, Amy S.; Gordon, Christopher L.; Goodpaster, Bret H.; Kuller, Lewis H.; Bunker, Clareann H.; Patrick, Alan L.; Wheeler, Victor W.; Orwoll, Eric; Zmuda, Joseph M.

In: Metabolism: Clinical and Experimental, Vol. 60, No. 8, 08.2011, p. 1178-1185.

Research output: Contribution to journalArticle

Miljkovic, I, Cauley, JA, Dressen, AS, Gordon, CL, Goodpaster, BH, Kuller, LH, Bunker, CH, Patrick, AL, Wheeler, VW, Orwoll, E & Zmuda, JM 2011, 'Bioactive androgens and glucuronidated androgen metabolites are associated with subcutaneous and ectopic skeletal muscle adiposity among older black men', Metabolism: Clinical and Experimental, vol. 60, no. 8, pp. 1178-1185. https://doi.org/10.1016/j.metabol.2010.12.014
Miljkovic, Iva ; Cauley, Jane A. ; Dressen, Amy S. ; Gordon, Christopher L. ; Goodpaster, Bret H. ; Kuller, Lewis H. ; Bunker, Clareann H. ; Patrick, Alan L. ; Wheeler, Victor W. ; Orwoll, Eric ; Zmuda, Joseph M. / Bioactive androgens and glucuronidated androgen metabolites are associated with subcutaneous and ectopic skeletal muscle adiposity among older black men. In: Metabolism: Clinical and Experimental. 2011 ; Vol. 60, No. 8. pp. 1178-1185.
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