TY - JOUR
T1 - Binge drinking impacts dorsal striatal response during decision making in adolescents
AU - Jones, Scott A.
AU - Cservenka, Anita
AU - Nagel, Bonnie J.
N1 - Funding Information:
Dr. Suzanne Mitchell is thanked for her feedback on preliminary drafts of this manuscript. Past and current members of the Developmental Brain Imaging Lab are thanked for assisting in participant scheduling and data collection. This research was supported by the National Institute on Alcohol Abuse and Alcoholism [T32 AA007468 (Phillips); R01 AA017664 (Nagel)].
Funding Information:
Dr. Suzanne Mitchell is thanked for her feedback on preliminary drafts of this manuscript. Past and current members of the Developmental Brain Imaging Lab are thanked for assisting in participant scheduling and data collection. This research was supported by the National Institute on Alcohol Abuse and Alcoholism [ T32 AA007468 (Phillips); R01 AA017664 (Nagel)].
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Adolescence is a time of both increased risk taking and increased vulnerability to the neurotoxic effects of alcohol. However, it is unclear whether brain functioning abnormalities in adolescent binge drinkers are a result of alcohol use itself or whether they represent premorbid risk characteristics. The current study addresses this question by using a modified version of the Wheel of Fortune (WOF) task, during functional magnetic resonance imaging (fMRI), at both baseline, while all subjects were alcohol-naïve, and revisit, when half of the subjects had emerged into regular binge drinking (n = 13) and half remained alcohol and substance-naïve (n = 13). Region of interest (ROI) analysis revealed that during decision making, there was a significant binge-drinking related reduction in brain activation in the dorsal striatum, an effect associated with degree of recent use. Furthermore, whole-brain analysis revealed a decrease in fronto-parietal brain activation prior to initiation of alcohol use, in adolescents who went on to binge drink. Additionally, there were numerous regions, both cortical and subcortical, in which there was a significant time-related developmental change, across groups. These results demonstrate how abnormalities in decision-making related circuitry might both lead to and perpetuate alcohol drinking behavior. These findings help aid in our ability to disentangle consequences of binge drinking from potential risk markers for future binge drinking, and may help guide future prevention and intervention strategies.
AB - Adolescence is a time of both increased risk taking and increased vulnerability to the neurotoxic effects of alcohol. However, it is unclear whether brain functioning abnormalities in adolescent binge drinkers are a result of alcohol use itself or whether they represent premorbid risk characteristics. The current study addresses this question by using a modified version of the Wheel of Fortune (WOF) task, during functional magnetic resonance imaging (fMRI), at both baseline, while all subjects were alcohol-naïve, and revisit, when half of the subjects had emerged into regular binge drinking (n = 13) and half remained alcohol and substance-naïve (n = 13). Region of interest (ROI) analysis revealed that during decision making, there was a significant binge-drinking related reduction in brain activation in the dorsal striatum, an effect associated with degree of recent use. Furthermore, whole-brain analysis revealed a decrease in fronto-parietal brain activation prior to initiation of alcohol use, in adolescents who went on to binge drink. Additionally, there were numerous regions, both cortical and subcortical, in which there was a significant time-related developmental change, across groups. These results demonstrate how abnormalities in decision-making related circuitry might both lead to and perpetuate alcohol drinking behavior. These findings help aid in our ability to disentangle consequences of binge drinking from potential risk markers for future binge drinking, and may help guide future prevention and intervention strategies.
KW - Adolescence
KW - Alcohol
KW - Binge
KW - Decision making
KW - Dorsal striatum
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U2 - 10.1016/j.neuroimage.2016.01.044
DO - 10.1016/j.neuroimage.2016.01.044
M3 - Article
C2 - 26826511
AN - SCOPUS:84957900807
VL - 129
SP - 378
EP - 388
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
ER -