TY - JOUR
T1 - Binge drinking and family history of alcoholism are associated with an altered developmental trajectory of impulsive choice across adolescence
AU - Jones, Scott A.
AU - Steele, Joel S.
AU - Nagel, Bonnie J.
N1 - Publisher Copyright:
© 2017 Society for the Study of Addiction
PY - 2017/7
Y1 - 2017/7
N2 - Aims: To test whether binge drinking, the density of familial alcoholism (FHD) and their interaction are associated with an altered developmental trajectory of impulsive choice across adolescence, and whether more life-time drinks are associated with a greater change in impulsive choice across age. Design: Alcohol-naive adolescents, with varying degrees of FHD, were recruited as part of an ongoing longitudinal study on adolescent development, and were grouped based on whether they remained non-drinkers (n = 83) or initiated binge drinking (n = 33) during follow-up. During all visits, adolescents completed a monetary delay discounting task to measure impulsive choice. The effects of binge-drinking status, FHD and their interaction on impulsive choice across adolescence were tested. Setting: Developmental Brain Imaging Laboratory, Oregon Health & Science University, Portland, Oregon, USA. Participants: A total of 116 healthy male and female adolescents (ages 10–17 years at baseline) completed two to four visits between July 2008 and May 2016. Measurements: Discounting rates were obtained based on adolescents' preference for immediate or delayed rewards. FHD was based on parent-reported prevalence of alcohol use disorder in the participant's first- and second-degree relatives. Binge-drinking status was determined based on the number of recent binge-drinking episodes. Findings: There was a significant interaction effect of binge-drinking status and FHD on impulsive choice across age (b = 1.090, P < 0.05, β = 0.298). In adolescents who remained alcohol-naive, greater FHD was associated with a steeper decrease in discounting rates across adolescence (b = −0.633, P < 0.05, β = −0.173); however, this effect was not present in binge-drinkers. Furthermore, total life-time drinks predicted escalated impulsive choice (b = 0.002, P < 0.05, β = 0.295) in binge-drinking adolescents. Conclusions: A greater degree of familial alcoholism is associated with a steeper decline in impulsive choice across adolescence, but only in those who remain alcohol-naive. Meanwhile, more life-time drinks during adolescence is associated with increases in impulsive choice across age.
AB - Aims: To test whether binge drinking, the density of familial alcoholism (FHD) and their interaction are associated with an altered developmental trajectory of impulsive choice across adolescence, and whether more life-time drinks are associated with a greater change in impulsive choice across age. Design: Alcohol-naive adolescents, with varying degrees of FHD, were recruited as part of an ongoing longitudinal study on adolescent development, and were grouped based on whether they remained non-drinkers (n = 83) or initiated binge drinking (n = 33) during follow-up. During all visits, adolescents completed a monetary delay discounting task to measure impulsive choice. The effects of binge-drinking status, FHD and their interaction on impulsive choice across adolescence were tested. Setting: Developmental Brain Imaging Laboratory, Oregon Health & Science University, Portland, Oregon, USA. Participants: A total of 116 healthy male and female adolescents (ages 10–17 years at baseline) completed two to four visits between July 2008 and May 2016. Measurements: Discounting rates were obtained based on adolescents' preference for immediate or delayed rewards. FHD was based on parent-reported prevalence of alcohol use disorder in the participant's first- and second-degree relatives. Binge-drinking status was determined based on the number of recent binge-drinking episodes. Findings: There was a significant interaction effect of binge-drinking status and FHD on impulsive choice across age (b = 1.090, P < 0.05, β = 0.298). In adolescents who remained alcohol-naive, greater FHD was associated with a steeper decrease in discounting rates across adolescence (b = −0.633, P < 0.05, β = −0.173); however, this effect was not present in binge-drinkers. Furthermore, total life-time drinks predicted escalated impulsive choice (b = 0.002, P < 0.05, β = 0.295) in binge-drinking adolescents. Conclusions: A greater degree of familial alcoholism is associated with a steeper decline in impulsive choice across adolescence, but only in those who remain alcohol-naive. Meanwhile, more life-time drinks during adolescence is associated with increases in impulsive choice across age.
KW - Adolescent
KW - alcohol
KW - decision-making
KW - genetic
KW - impulsivity
KW - longitudinal
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U2 - 10.1111/add.13823
DO - 10.1111/add.13823
M3 - Article
C2 - 28317212
AN - SCOPUS:85018605321
SN - 0965-2140
VL - 112
SP - 1184
EP - 1192
JO - Addiction
JF - Addiction
IS - 7
ER -