Bedside Back to Bench

Building Bridges between Basic and Clinical Genomic Research

Teri A. Manolio, Douglas M. Fowler, Lea M. Starita, Melissa Haendel, Daniel G. MacArthur, Leslie G. Biesecker, Elizabeth Worthey, Rex L. Chisholm, Eric D. Green, Howard J. Jacob, Howard L. McLeod, Dan Roden, Laura Lyman Rodriguez, Marc S. Williams, Gregory M. Cooper, Nancy J. Cox, Gail E. Herman, Stephen Kingsmore, Cecilia Lo, Cathleen Lutz & 11 others Calum A. MacRae, Robert L. Nussbaum, Jose M. Ordovas, Erin M. Ramos, Peter N. Robinson, Wendy S. Rubinstein, Christine Seidman, Barbara E. Stranger, Haoyi Wang, Monte Westerfield, Carol Bult

Research output: Contribution to journalComment/debate

39 Citations (Scopus)

Abstract

Genome sequencing has revolutionized the diagnosis of genetic diseases. Close collaborations between basic scientists and clinical genomicists are now needed to link genetic variants with disease causation. To facilitate such collaborations, we recommend prioritizing clinically relevant genes for functional studies, developing reference variant-phenotype databases, adopting phenotype description standards, and promoting data sharing.

Original languageEnglish (US)
Pages (from-to)6-12
Number of pages7
JournalCell
Volume169
Issue number1
DOIs
StatePublished - Mar 23 2017

Fingerprint

Genes
Phenotype
Inborn Genetic Diseases
Information Dissemination
Research
Causality
Genome
Databases

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Manolio, T. A., Fowler, D. M., Starita, L. M., Haendel, M., MacArthur, D. G., Biesecker, L. G., ... Bult, C. (2017). Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research. Cell, 169(1), 6-12. https://doi.org/10.1016/j.cell.2017.03.005

Bedside Back to Bench : Building Bridges between Basic and Clinical Genomic Research. / Manolio, Teri A.; Fowler, Douglas M.; Starita, Lea M.; Haendel, Melissa; MacArthur, Daniel G.; Biesecker, Leslie G.; Worthey, Elizabeth; Chisholm, Rex L.; Green, Eric D.; Jacob, Howard J.; McLeod, Howard L.; Roden, Dan; Rodriguez, Laura Lyman; Williams, Marc S.; Cooper, Gregory M.; Cox, Nancy J.; Herman, Gail E.; Kingsmore, Stephen; Lo, Cecilia; Lutz, Cathleen; MacRae, Calum A.; Nussbaum, Robert L.; Ordovas, Jose M.; Ramos, Erin M.; Robinson, Peter N.; Rubinstein, Wendy S.; Seidman, Christine; Stranger, Barbara E.; Wang, Haoyi; Westerfield, Monte; Bult, Carol.

In: Cell, Vol. 169, No. 1, 23.03.2017, p. 6-12.

Research output: Contribution to journalComment/debate

Manolio, TA, Fowler, DM, Starita, LM, Haendel, M, MacArthur, DG, Biesecker, LG, Worthey, E, Chisholm, RL, Green, ED, Jacob, HJ, McLeod, HL, Roden, D, Rodriguez, LL, Williams, MS, Cooper, GM, Cox, NJ, Herman, GE, Kingsmore, S, Lo, C, Lutz, C, MacRae, CA, Nussbaum, RL, Ordovas, JM, Ramos, EM, Robinson, PN, Rubinstein, WS, Seidman, C, Stranger, BE, Wang, H, Westerfield, M & Bult, C 2017, 'Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research', Cell, vol. 169, no. 1, pp. 6-12. https://doi.org/10.1016/j.cell.2017.03.005
Manolio TA, Fowler DM, Starita LM, Haendel M, MacArthur DG, Biesecker LG et al. Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research. Cell. 2017 Mar 23;169(1):6-12. https://doi.org/10.1016/j.cell.2017.03.005
Manolio, Teri A. ; Fowler, Douglas M. ; Starita, Lea M. ; Haendel, Melissa ; MacArthur, Daniel G. ; Biesecker, Leslie G. ; Worthey, Elizabeth ; Chisholm, Rex L. ; Green, Eric D. ; Jacob, Howard J. ; McLeod, Howard L. ; Roden, Dan ; Rodriguez, Laura Lyman ; Williams, Marc S. ; Cooper, Gregory M. ; Cox, Nancy J. ; Herman, Gail E. ; Kingsmore, Stephen ; Lo, Cecilia ; Lutz, Cathleen ; MacRae, Calum A. ; Nussbaum, Robert L. ; Ordovas, Jose M. ; Ramos, Erin M. ; Robinson, Peter N. ; Rubinstein, Wendy S. ; Seidman, Christine ; Stranger, Barbara E. ; Wang, Haoyi ; Westerfield, Monte ; Bult, Carol. / Bedside Back to Bench : Building Bridges between Basic and Clinical Genomic Research. In: Cell. 2017 ; Vol. 169, No. 1. pp. 6-12.
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AU - MacArthur, Daniel G.

AU - Biesecker, Leslie G.

AU - Worthey, Elizabeth

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AU - Ordovas, Jose M.

AU - Ramos, Erin M.

AU - Robinson, Peter N.

AU - Rubinstein, Wendy S.

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AU - Wang, Haoyi

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