Baseline psychopathology and relationship to longitudinal functional outcome in attenuated and early first episode psychosis

Cynthia Z. Burton, Ivy F. Tso, Ricardo E. Carrión, Tara Niendam, Steven Adelsheim, Andrea M. Auther, Barbara A. Cornblatt, Cameron S. Carter, Ryan Melton, Tamara G. Sale, Stephan F. Taylor, William R. McFarlane

Research output: Contribution to journalArticle

Abstract

Background: As efforts intensify to intervene early among those at risk for psychosis, examination of the relationship between presenting psychopathology and long-term functional outcome may guide treatment decision-making and offer a means to prevent or reduce chronic disability. Methods: Data were collected through the Early Detection and Intervention for the Prevention of Psychosis Program (EDIPPP), a multisite national trial testing the efficacy of an early intervention for youth at risk of developing psychosis. Participants were followed prospectively and completed comprehensive evaluations at 6, 12, and 24 months, including the Structured Interview for Prodromal Syndromes (SIPS) and the Global Social and Role Functioning Scales. The present analyses included 327 participants and examined the relationships between baseline symptoms and longitudinal global social and role functioning using a linear mixed modeling approach. Results: Higher baseline negative symptoms and deteriorated thought process predicted worse social and role functioning in the follow-up period. The effect of negative symptoms on social functioning, however, was moderated by positive symptoms, and the relationship between positive symptoms and social functioning changed over time. Baseline positive symptoms, distress, and level of symptom severity were not predictors of either social or role functioning. Conclusions: Baseline negative symptoms and thought disorder appear to predict functional outcome for up to two years among adolescents and young adults at risk for psychosis. Developing effective interventions to target these symptoms may be critical to promote functional recovery among those experiencing attenuated symptoms or a first episode of psychosis.

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalSchizophrenia Research
Volume212
DOIs
StatePublished - Oct 2019

Keywords

  • Attenuated psychosis
  • Clinical high risk
  • Functioning
  • Negative symptoms
  • Positive symptoms

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Burton, C. Z., Tso, I. F., Carrión, R. E., Niendam, T., Adelsheim, S., Auther, A. M., Cornblatt, B. A., Carter, C. S., Melton, R., Sale, T. G., Taylor, S. F., & McFarlane, W. R. (2019). Baseline psychopathology and relationship to longitudinal functional outcome in attenuated and early first episode psychosis. Schizophrenia Research, 212, 157-162. https://doi.org/10.1016/j.schres.2019.07.048