Basal lamina and the organization of neuromuscular synapses

Bruce Patton

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Fast chemical synapses are comprised of presynaptic and postsynaptic specializations precisely aligned across a protein-filled synaptic cleft. At the vertebrate neuromuscular junction (NMJ), the synaptic cleft contains a structured form of extracellular matrix known as a basal lamina (BL). Synaptic BL is molecularly differentiated from the BL that covers the extrasynaptic region of the myofiber. This review summarizes current understanding of the morphology composition, and function of the synaptic BL at the vertebrate NMJ. Considerable evidence supports the conclusion that the synaptic BL organizes and maintains pre-and postsynaptic specializations during development and regeneration, and promotes robust neurotransmission in the adult.

Original languageEnglish (US)
Pages (from-to)883-903
Number of pages21
JournalJournal of Neurocytology
Volume32
Issue number5-8
DOIs
StatePublished - Jun 2003

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Basement Membrane
Synapses
Neuromuscular Junction
Vertebrates
Synaptic Transmission
Extracellular Matrix
Regeneration
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Anatomy
  • Cell Biology
  • Histology

Cite this

Basal lamina and the organization of neuromuscular synapses. / Patton, Bruce.

In: Journal of Neurocytology, Vol. 32, No. 5-8, 06.2003, p. 883-903.

Research output: Contribution to journalArticle

Patton, Bruce. / Basal lamina and the organization of neuromuscular synapses. In: Journal of Neurocytology. 2003 ; Vol. 32, No. 5-8. pp. 883-903.
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