Basal lamina and the organization of neuromuscular synapses

Bruce L. Patton

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

Fast chemical synapses are comprised of presynaptic and postsynaptic specializations precisely aligned across a protein-filled synaptic cleft. At the vertebrate neuromuscular junction (NMJ), the synaptic cleft contains a structured form of extracellular matrix known as a basal lamina (BL). Synaptic BL is molecularly differentiated from the BL that covers the extrasynaptic region of the myofiber. This review summarizes current understanding of the morphology composition, and function of the synaptic BL at the vertebrate NMJ. Considerable evidence supports the conclusion that the synaptic BL organizes and maintains pre-and postsynaptic specializations during development and regeneration, and promotes robust neurotransmission in the adult.

Original languageEnglish (US)
Pages (from-to)883-903
Number of pages21
JournalJournal of Neurocytology
Volume32
Issue number5-8
DOIs
StatePublished - Jun 1 2003

ASJC Scopus subject areas

  • Anatomy
  • Neuroscience(all)
  • Histology
  • Cell Biology

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