Baroreceptor response to modeled aortic pressure

K. D. Alfrey, J. W. Clark, J. H. Schild, Michael Andresen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have developed, using pressure data from rat, a hemodynamic model of the left ventricle and systemic arteries, which produces realistic representations of aortic pressure. These model-generated pressures are applied to a previously-developed model of a rat aortic baroreceptor (BR) in order to predict the response of individual BR fibers with varying threshold characteristics. We find that the majority of fibers respond to normal physiological pressure inputs by producing a bursting pattern of firing. It has been demonstrated previously that such patterns are preferentially propagated by the mNTS, the brain center most involved with processing afferent BR information.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Pages257
Number of pages1
Volume1
ISBN (Print)0780356756
Publication statusPublished - 1999
Externally publishedYes
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

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ASJC Scopus subject areas

  • Bioengineering

Cite this

Alfrey, K. D., Clark, J. W., Schild, J. H., & Andresen, M. (1999). Baroreceptor response to modeled aortic pressure. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 1, pp. 257). IEEE.