Balance of yin and yang: Ubiquitylation-mediated regulation of p53 and c-Myc

Mu Shui Dai, Yetao Jin, Jayme R. Gallegos, Hua Lu

Research output: Contribution to journalReview article

55 Scopus citations

Abstract

Protein ubiquitylation has been demonstrated to play a vital role not only in mediating protein turnover but also in modulating protein activity. The stability and activity of the tumor suppressor p53 and of the oncoprotein c-Myc are no exception. Both are regulated through independent ubiquitylation by several E3 ubiquitin ligases. Interestingly, p53 and c-Myc are functionally connected by some of these E3 enzymes and their regulator ARF, although these proteins play opposite roles in controlling cell growth and proliferation. The balance of this complex ubiquitylation network and its disruption during oncogenesis will be the topics of this review.

Original languageEnglish (US)
Pages (from-to)630-644
Number of pages15
JournalNeoplasia
Volume8
Issue number8
DOIs
StatePublished - 2006

Keywords

  • Oncogenesis
  • Ubiquitylation
  • Yin and yang
  • c-Myc
  • p53

ASJC Scopus subject areas

  • Cancer Research

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