B-Adrenergic receptor stimulation increases anti-DNA antibody production in MRL/1pr mice

K. Colburn, R. Boucek, G. Gusewitch, A. Wong, P. Wat, Douglas Weeks

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

To gain insight into a role for excessive B-adrenergic receptor stimulation in the pathogenesis of autoimmune diseases, MRL/1pr mice were chronically injected with isoproterenol. The mean change of serum antibody levels after one month of treatment was higher in the isoproterenol treated mice than in controls (anti-ssDNA, p <0.05; anti-nDNA, p <0.04; and antiguanosine antibodies, p <0.03) without significant differences in serum IgG levels. Additionally, mean serum creatinine levels were higher and glomerulonephritis more severe in the isoproterenol treated group. Our findings provide the first evidence linking aberrant B-adrenergic receptor activities, serum anti-DNA antibodies, and end-organ pathology in an animal model of lupus nephritis.

Original languageEnglish (US)
Pages (from-to)138-141
Number of pages4
JournalJournal of Rheumatology
Volume17
Issue number2
StatePublished - 1990
Externally publishedYes

Fingerprint

Antinuclear Antibodies
Adrenergic Receptors
Antibody Formation
Isoproterenol
Serum
Lupus Nephritis
Antibodies
Glomerulonephritis
Autoimmune Diseases
Creatinine
Animal Models
Immunoglobulin G
Pathology

Keywords

  • Anti-DNA antibodies
  • Antiguanosine antibodies
  • B-Adrenergic receptors
  • Lupus nephritis
  • MRL/1pr mice
  • Stress

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Colburn, K., Boucek, R., Gusewitch, G., Wong, A., Wat, P., & Weeks, D. (1990). B-Adrenergic receptor stimulation increases anti-DNA antibody production in MRL/1pr mice. Journal of Rheumatology, 17(2), 138-141.

B-Adrenergic receptor stimulation increases anti-DNA antibody production in MRL/1pr mice. / Colburn, K.; Boucek, R.; Gusewitch, G.; Wong, A.; Wat, P.; Weeks, Douglas.

In: Journal of Rheumatology, Vol. 17, No. 2, 1990, p. 138-141.

Research output: Contribution to journalArticle

Colburn, K, Boucek, R, Gusewitch, G, Wong, A, Wat, P & Weeks, D 1990, 'B-Adrenergic receptor stimulation increases anti-DNA antibody production in MRL/1pr mice', Journal of Rheumatology, vol. 17, no. 2, pp. 138-141.
Colburn K, Boucek R, Gusewitch G, Wong A, Wat P, Weeks D. B-Adrenergic receptor stimulation increases anti-DNA antibody production in MRL/1pr mice. Journal of Rheumatology. 1990;17(2):138-141.
Colburn, K. ; Boucek, R. ; Gusewitch, G. ; Wong, A. ; Wat, P. ; Weeks, Douglas. / B-Adrenergic receptor stimulation increases anti-DNA antibody production in MRL/1pr mice. In: Journal of Rheumatology. 1990 ; Vol. 17, No. 2. pp. 138-141.
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