Axial kinesthesia is impaired in Parkinson's disease: Effects of levodopa

W. G. Wright, V. S. Gurfinkel, Laurie King, John Nutt, Paul Cordo, Fay Horak

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Integration of sensory and motor inputs has been shown to be impaired in appendicular muscles and joints of Parkinson's disease (PD) patients. As PD advances, axial symptoms such as gait and balance impairments appear, which often progresses to complete inability stand or walk unaided. The current study evaluates kinesthesia in the axial musculature of PD patients during active postural control to determine whether impairments similar to those found in the appendages are also present in the hip and trunk. Using axial twisting, we quantified the detection threshold and directional accuracy of the hip relative to the feet (i.e. Hip Kinesthesia) and the hip relative to the shoulders (i.e. Trunk Kinesthesia). The relation of kinesthetic threshold to disease progression as measured by UPDRS and the effect of levodopa treatment on kinesthesia were assessed in 12 PD compared to age-matched controls. Subjects stood unaided while passively twisted at a very low constant rotational velocity (1°/s). The results showed that accuracy in determining the direction of axial twisting was reduced in PD relative to healthy control subjects in the hip (PD-ON: 81%; PD-OFF: 91%; CTL. =96%) and trunk (PD-ON: 81%; PD-OFF: 88%; CTL=95%). Thresholds for perception of axial twisting were increased when PD subjects were ON levodopa versus OFF in both the hip (p

Original languageEnglish (US)
Pages (from-to)202-209
Number of pages8
JournalExperimental Neurology
Volume225
Issue number1
DOIs
Publication statusPublished - Sep 2010

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Keywords

  • Axial musculature
  • Hypertonicity
  • Kinesthesia
  • Levodopa
  • Muscle tone
  • Perceptual asymmetry
  • Rigidity

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Medicine(all)

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