Autopsy findings in aids patients with mycobacterium avium complex bacteremia

Francesca J. Torriani, J. Allen Mc Cutchan, Samuel A. Bozzette, Marjorie R. Grafe, Diane V. Havlir

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

To study the pathogenesis of Mycobacterium avium complex (MAC) bacteremia, the extent of organ involvement was determined in a retrospective cohort of 44 AIDS patients with MAC bacteremia and complete autopsies between 1988 and 1992. Clinical and microbiologic histories were reviewed and lymph nodes, spleen, liver, bone marrow, small intestine, and colon from each autopsy were systematically evaluated for the presence of mycobacteria or foamy histiocytes. Of the patients, 30% had no histologic evidence ofMAC. In the remaining 70%, reticuloendothelial and gastrointestinal involvement was most common, but the number and distribution of involved sites was highly variable. The risk of developing detectable histologic involvement was related to the duration of bacteremia. In contrast to the prevailing concept, our data suggest that MAC bacteremia may precede widespread tissue disease.

Original languageEnglish (US)
Pages (from-to)1601-1605
Number of pages5
JournalJournal of Infectious Diseases
Volume170
Issue number6
DOIs
StatePublished - Dec 1994

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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