Autopsy findings in AIDS patients with Mycobacterium avium complex bacteremia

Francesca J. Torriani, J. Allen McCutchan, Samuel A. Bozzette, Marjorie Grafe, Diane Y. Havlir

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

To study the pathogenesis of Mycobacterium avium complex (MAC) bacteremia, the extent of organ involvement was determined in a retrospective cohort of 44 AIDS patients with MAC bacteremia and complete autopsies between 1988 and 1992. Clinical and microbiologic histories were reviewed and lymph nodes, spleen, liver, bone marrow, small intestine, and colon from each autopsy were systematically evaluated for the presence of mycobacteria or foamy histiocytes. Of the patients, 30% had no histologic evidence of MAC. In the remaining 70%, reticuloendothelial and gastrointestinal involvement was most common, but the number and distribution of involved sites was highly variable. The risk of developing detectable histologic involvement was related to the duration of bacteremia. In contrast to the prevailing concept, our data suggest that MAC bacteremia may precede widespread tissue disease.

Original languageEnglish (US)
Pages (from-to)1601-1605
Number of pages5
JournalJournal of Infectious Diseases
Volume170
Issue number6
StatePublished - Dec 1994
Externally publishedYes

Fingerprint

Mycobacterium avium Complex
Bacteremia
Autopsy
Acquired Immunodeficiency Syndrome
Histiocytes
Mycobacterium
Small Intestine
Colon
Spleen
Lymph Nodes
Bone Marrow
Liver

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Torriani, F. J., McCutchan, J. A., Bozzette, S. A., Grafe, M., & Havlir, D. Y. (1994). Autopsy findings in AIDS patients with Mycobacterium avium complex bacteremia. Journal of Infectious Diseases, 170(6), 1601-1605.

Autopsy findings in AIDS patients with Mycobacterium avium complex bacteremia. / Torriani, Francesca J.; McCutchan, J. Allen; Bozzette, Samuel A.; Grafe, Marjorie; Havlir, Diane Y.

In: Journal of Infectious Diseases, Vol. 170, No. 6, 12.1994, p. 1601-1605.

Research output: Contribution to journalArticle

Torriani, FJ, McCutchan, JA, Bozzette, SA, Grafe, M & Havlir, DY 1994, 'Autopsy findings in AIDS patients with Mycobacterium avium complex bacteremia', Journal of Infectious Diseases, vol. 170, no. 6, pp. 1601-1605.
Torriani FJ, McCutchan JA, Bozzette SA, Grafe M, Havlir DY. Autopsy findings in AIDS patients with Mycobacterium avium complex bacteremia. Journal of Infectious Diseases. 1994 Dec;170(6):1601-1605.
Torriani, Francesca J. ; McCutchan, J. Allen ; Bozzette, Samuel A. ; Grafe, Marjorie ; Havlir, Diane Y. / Autopsy findings in AIDS patients with Mycobacterium avium complex bacteremia. In: Journal of Infectious Diseases. 1994 ; Vol. 170, No. 6. pp. 1601-1605.
@article{52b96a6a269d430d81fa9a126984eb5c,
title = "Autopsy findings in AIDS patients with Mycobacterium avium complex bacteremia",
abstract = "To study the pathogenesis of Mycobacterium avium complex (MAC) bacteremia, the extent of organ involvement was determined in a retrospective cohort of 44 AIDS patients with MAC bacteremia and complete autopsies between 1988 and 1992. Clinical and microbiologic histories were reviewed and lymph nodes, spleen, liver, bone marrow, small intestine, and colon from each autopsy were systematically evaluated for the presence of mycobacteria or foamy histiocytes. Of the patients, 30{\%} had no histologic evidence of MAC. In the remaining 70{\%}, reticuloendothelial and gastrointestinal involvement was most common, but the number and distribution of involved sites was highly variable. The risk of developing detectable histologic involvement was related to the duration of bacteremia. In contrast to the prevailing concept, our data suggest that MAC bacteremia may precede widespread tissue disease.",
author = "Torriani, {Francesca J.} and McCutchan, {J. Allen} and Bozzette, {Samuel A.} and Marjorie Grafe and Havlir, {Diane Y.}",
year = "1994",
month = "12",
language = "English (US)",
volume = "170",
pages = "1601--1605",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Autopsy findings in AIDS patients with Mycobacterium avium complex bacteremia

AU - Torriani, Francesca J.

AU - McCutchan, J. Allen

AU - Bozzette, Samuel A.

AU - Grafe, Marjorie

AU - Havlir, Diane Y.

PY - 1994/12

Y1 - 1994/12

N2 - To study the pathogenesis of Mycobacterium avium complex (MAC) bacteremia, the extent of organ involvement was determined in a retrospective cohort of 44 AIDS patients with MAC bacteremia and complete autopsies between 1988 and 1992. Clinical and microbiologic histories were reviewed and lymph nodes, spleen, liver, bone marrow, small intestine, and colon from each autopsy were systematically evaluated for the presence of mycobacteria or foamy histiocytes. Of the patients, 30% had no histologic evidence of MAC. In the remaining 70%, reticuloendothelial and gastrointestinal involvement was most common, but the number and distribution of involved sites was highly variable. The risk of developing detectable histologic involvement was related to the duration of bacteremia. In contrast to the prevailing concept, our data suggest that MAC bacteremia may precede widespread tissue disease.

AB - To study the pathogenesis of Mycobacterium avium complex (MAC) bacteremia, the extent of organ involvement was determined in a retrospective cohort of 44 AIDS patients with MAC bacteremia and complete autopsies between 1988 and 1992. Clinical and microbiologic histories were reviewed and lymph nodes, spleen, liver, bone marrow, small intestine, and colon from each autopsy were systematically evaluated for the presence of mycobacteria or foamy histiocytes. Of the patients, 30% had no histologic evidence of MAC. In the remaining 70%, reticuloendothelial and gastrointestinal involvement was most common, but the number and distribution of involved sites was highly variable. The risk of developing detectable histologic involvement was related to the duration of bacteremia. In contrast to the prevailing concept, our data suggest that MAC bacteremia may precede widespread tissue disease.

UR - http://www.scopus.com/inward/record.url?scp=0028117639&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028117639&partnerID=8YFLogxK

M3 - Article

VL - 170

SP - 1601

EP - 1605

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 6

ER -