Automated spectroscopic retinal oximetry with visible-light optical coherence tomography

Shaohua Pi; Acner Camino; William Cepurna; Xiang Wei; Miao Zhang; David Huang; John Morrison; Yali Jia

doi:10.1364/BOE.9.002056

Automated spectroscopic retinal oximetry with visible-light optical coherence tomography

Shaohua Pi, Acner Camino, William Cepurna, Xiang Wei, Miao Zhang, David Huang, John Morrison, Yali Jia

Ophthalmology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Accurate, quantitative assessment of retinal blood oxygen saturation (sO₂) may provide a useful early indicator of pathophysiology in several ocular diseases. Here, with visible-light optical coherence tomography (OCT), we demonstrate an automated spectroscopic retinal oximetry algorithm to measure the sO₂ within the retinal arteries (A-sO₂) and veins (V-sO₂) in rats by automatically detecting the vascular posterior boundary on crosssectional structural OCT. The algorithm was validated in vitro with flow phantoms and in vivo in rats by comparing the sO₂ results, respectively, to those obtained using a blood gas analyzer and pulse oximetry. We also investigated the response of oxygen extraction (A-V sO₂), including inter-session reproducibility, at different inhaled oxygen concentrations.

Original language	English (US)
Article number	#320440
Pages (from-to)	2056-2067
Number of pages	12
Journal	Biomedical Optics Express
Volume	9
Issue number	5
DOIs	https://doi.org/10.1364/BOE.9.002056
State	Published - May 1 2018

Keywords

Functional monitoring and imaging
Image enhancement
Ophthalmology
Optical coherence tomography

ASJC Scopus subject areas

Biotechnology
Atomic and Molecular Physics, and Optics

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10.1364/BOE.9.002056

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abstract = "Accurate, quantitative assessment of retinal blood oxygen saturation (sO2) may provide a useful early indicator of pathophysiology in several ocular diseases. Here, with visible-light optical coherence tomography (OCT), we demonstrate an automated spectroscopic retinal oximetry algorithm to measure the sO2 within the retinal arteries (A-sO2) and veins (V-sO2) in rats by automatically detecting the vascular posterior boundary on crosssectional structural OCT. The algorithm was validated in vitro with flow phantoms and in vivo in rats by comparing the sO2 results, respectively, to those obtained using a blood gas analyzer and pulse oximetry. We also investigated the response of oxygen extraction (A-V sO2), including inter-session reproducibility, at different inhaled oxygen concentrations.",

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AU - Cepurna, William

AU - Wei, Xiang

AU - Zhang, Miao

AU - Huang, David

AU - Morrison, John

AU - Jia, Yali

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Automated spectroscopic retinal oximetry with visible-light optical coherence tomography

Abstract

Keywords

ASJC Scopus subject areas

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