Automated phase unwrapping in Doppler optical coherence tomography

Shaohua Pi, Acner Camino, Xiang Wei, Tristan T. Hormel, William Cepurna, John Morrison, Jia Yali

Research output: Contribution to journalArticle

Abstract

Phase wrapping is a crucial issue in Doppler optical coherence tomography (OCT) and restricts its automatic implementation for clinical applications that quantify total retinal blood flow. We propose an automated phase-unwrapping technique that takes advantage of the parabolic profile of blood flow velocity in vessels. Instead of inspecting the phase shift manually, the algorithm calculates the gradient magnitude of the phase shift on the cross-sectional image and automatically detects the presence of phase wrapping. The voxels affected by phase wrapping are corrected according to the determined flow direction adjacent to the vessel walls. We validated this technique in the rodent retina using a prototype visible-light OCT and in the human retina with a commercial infrared OCT system. We believe this signal processing method may well accelerate clinical applications of Doppler OCT in ophthalmology.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalJournal of Biomedical Optics
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Optical tomography
tomography
retina
blood flow
Phase shift
vessels
Blood
phase shift
Ophthalmology
ophthalmology
rodents
Flow velocity
signal processing
Signal processing
flow velocity
prototypes
Infrared radiation
gradients
profiles

Keywords

  • Doppler optical coherence tomography
  • imaging processing
  • ophthalmology
  • optical coherence tomography
  • total retinal blood flow

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Cite this

Automated phase unwrapping in Doppler optical coherence tomography. / Pi, Shaohua; Camino, Acner; Wei, Xiang; Hormel, Tristan T.; Cepurna, William; Morrison, John; Yali, Jia.

In: Journal of Biomedical Optics, Vol. 24, No. 1, 01.01.2019, p. 1-4.

Research output: Contribution to journalArticle

Pi, Shaohua ; Camino, Acner ; Wei, Xiang ; Hormel, Tristan T. ; Cepurna, William ; Morrison, John ; Yali, Jia. / Automated phase unwrapping in Doppler optical coherence tomography. In: Journal of Biomedical Optics. 2019 ; Vol. 24, No. 1. pp. 1-4.
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