TY - JOUR
T1 - Autologous Fat Injection for Vocal Fold Paralysis
T2 - Long-Term Histologic Evaluation
AU - Zaretsky, Lauren S.
AU - Detar, Michael
AU - Shindo, Maisie L.
AU - Rice, Dale H.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1995/1
Y1 - 1995/1
N2 - Many techniques have been developed for medialization of the paralyzed vocal fold. The purpose of this study is to evaluate autologous fat as an alternative to alloplastic substances for use in vocal fold medialization. Eight dogs underwent left recurrent laryngeal nerve sectioning. Autologous fat was harvested, and the paralyzed vocal fold was medialized by injecting the fat into the thyroarytenoid muscle. The animals were divided into three groups for evaluation at 1, 3, and 6 months. Videolaryngoscopy was performed prior to sacrificing the animals. The larynges were sectioned coronally, and histologic studies were performed. The studies confirmed the preservation of viable fat at the injected site in all animals. Only a minimal inflammatory response was observed in the 1-month group. It would appear that fat injection is a viable alternative to Teflon injection and thyroplasty; it eliminates the need for alloplastic materials, does not appear to migrate, and does not require an open procedure.
AB - Many techniques have been developed for medialization of the paralyzed vocal fold. The purpose of this study is to evaluate autologous fat as an alternative to alloplastic substances for use in vocal fold medialization. Eight dogs underwent left recurrent laryngeal nerve sectioning. Autologous fat was harvested, and the paralyzed vocal fold was medialized by injecting the fat into the thyroarytenoid muscle. The animals were divided into three groups for evaluation at 1, 3, and 6 months. Videolaryngoscopy was performed prior to sacrificing the animals. The larynges were sectioned coronally, and histologic studies were performed. The studies confirmed the preservation of viable fat at the injected site in all animals. Only a minimal inflammatory response was observed in the 1-month group. It would appear that fat injection is a viable alternative to Teflon injection and thyroplasty; it eliminates the need for alloplastic materials, does not appear to migrate, and does not require an open procedure.
KW - autologous fat injection
KW - histology
KW - vocal fold medialization
KW - vocal fold paralysis
UR - http://www.scopus.com/inward/record.url?scp=0028893344&partnerID=8YFLogxK
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U2 - 10.1177/000348949510400101
DO - 10.1177/000348949510400101
M3 - Article
C2 - 7832536
AN - SCOPUS:0028893344
SN - 0003-4894
VL - 104
SP - 1
EP - 4
JO - Annals of Otology, Rhinology & Laryngology
JF - Annals of Otology, Rhinology & Laryngology
IS - 1
ER -