Attempted induction of chronic portal venous hypertension with polyvinyl alcohol particles in swine

Dusan Pavcnik, Richard R. Saxon, Yasushi Kubota, Hirohiko Tanihata, Barry Uchida, Christopher Corless, Frederick Keller

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

PURPOSE: Creation of presinusoidal chronic portal venous hypertension by means of repeated portal vein (PV) embolization was explored in an attempt to improve a porcine model of transjugular intrahepatic portosystemic shunt (TIPS) patency. MATERIALS AND METHODS: Six microswine underwent weekly PV embolization for 5 weeks with a total of 10.4-12.6 g of polyvinyl alcohol (PVA) particles (0.149-0.250 mm in size). Portography, liver function tests, pressure measurement in the PV and inferior vena cava (IVC) before and after PV embolization, and histopathologic evaluation of the livers were performed. RESULTS: Transhepatic portal venography performed after each embolization demonstrated diffuse PV branch occlusion in all cases. At weekly follow-up, reconstitution of flow was demonstrated in these branches; permanent occlusion of PV branches was not achieved. The mean PV pressure elevated acutely from 17.3 mm Hg ± 0.9 to 24.5 mm Hg ± 4.2 (P <.01) after each embolization. However, the pressure always returned to baseline on the follow-up studies 1 week later. Liver function tests were normal. Histopathologic evaluation of the liver showed, in multiple PV branches, central plugs of PVA with peripheral recanalization. The liver parenchyma was otherwise normal. CONCLUSION: Massive embolizations of PV with PVA at weekly intervals failed to create permanent portal hypertension or induce hepatic fibrosis.

Original languageEnglish (US)
Pages (from-to)123-128
Number of pages6
JournalJournal of Vascular and Interventional Radiology
Volume8
Issue number1
StatePublished - Jan 1997

Fingerprint

Polyvinyl Alcohol
Portal Hypertension
Portal Vein
Swine
Liver
Liver Function Tests
Portography
Transjugular Intrahepatic Portasystemic Shunt
Portal Pressure
Pressure
Phlebography
Inferior Vena Cava
Fibrosis

Keywords

  • Hypertension, portal
  • Liver, blood supply
  • Liver, interventional procedure
  • Portal vein, flow dynamics
  • Shunts, portosystemic

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Attempted induction of chronic portal venous hypertension with polyvinyl alcohol particles in swine. / Pavcnik, Dusan; Saxon, Richard R.; Kubota, Yasushi; Tanihata, Hirohiko; Uchida, Barry; Corless, Christopher; Keller, Frederick.

In: Journal of Vascular and Interventional Radiology, Vol. 8, No. 1, 01.1997, p. 123-128.

Research output: Contribution to journalArticle

@article{da5e1bc5742340da8e2dba0de5048a8f,
title = "Attempted induction of chronic portal venous hypertension with polyvinyl alcohol particles in swine",
abstract = "PURPOSE: Creation of presinusoidal chronic portal venous hypertension by means of repeated portal vein (PV) embolization was explored in an attempt to improve a porcine model of transjugular intrahepatic portosystemic shunt (TIPS) patency. MATERIALS AND METHODS: Six microswine underwent weekly PV embolization for 5 weeks with a total of 10.4-12.6 g of polyvinyl alcohol (PVA) particles (0.149-0.250 mm in size). Portography, liver function tests, pressure measurement in the PV and inferior vena cava (IVC) before and after PV embolization, and histopathologic evaluation of the livers were performed. RESULTS: Transhepatic portal venography performed after each embolization demonstrated diffuse PV branch occlusion in all cases. At weekly follow-up, reconstitution of flow was demonstrated in these branches; permanent occlusion of PV branches was not achieved. The mean PV pressure elevated acutely from 17.3 mm Hg ± 0.9 to 24.5 mm Hg ± 4.2 (P <.01) after each embolization. However, the pressure always returned to baseline on the follow-up studies 1 week later. Liver function tests were normal. Histopathologic evaluation of the liver showed, in multiple PV branches, central plugs of PVA with peripheral recanalization. The liver parenchyma was otherwise normal. CONCLUSION: Massive embolizations of PV with PVA at weekly intervals failed to create permanent portal hypertension or induce hepatic fibrosis.",
keywords = "Hypertension, portal, Liver, blood supply, Liver, interventional procedure, Portal vein, flow dynamics, Shunts, portosystemic",
author = "Dusan Pavcnik and Saxon, {Richard R.} and Yasushi Kubota and Hirohiko Tanihata and Barry Uchida and Christopher Corless and Frederick Keller",
year = "1997",
month = "1",
language = "English (US)",
volume = "8",
pages = "123--128",
journal = "Journal of Vascular and Interventional Radiology",
issn = "1051-0443",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Attempted induction of chronic portal venous hypertension with polyvinyl alcohol particles in swine

AU - Pavcnik, Dusan

AU - Saxon, Richard R.

AU - Kubota, Yasushi

AU - Tanihata, Hirohiko

AU - Uchida, Barry

AU - Corless, Christopher

AU - Keller, Frederick

PY - 1997/1

Y1 - 1997/1

N2 - PURPOSE: Creation of presinusoidal chronic portal venous hypertension by means of repeated portal vein (PV) embolization was explored in an attempt to improve a porcine model of transjugular intrahepatic portosystemic shunt (TIPS) patency. MATERIALS AND METHODS: Six microswine underwent weekly PV embolization for 5 weeks with a total of 10.4-12.6 g of polyvinyl alcohol (PVA) particles (0.149-0.250 mm in size). Portography, liver function tests, pressure measurement in the PV and inferior vena cava (IVC) before and after PV embolization, and histopathologic evaluation of the livers were performed. RESULTS: Transhepatic portal venography performed after each embolization demonstrated diffuse PV branch occlusion in all cases. At weekly follow-up, reconstitution of flow was demonstrated in these branches; permanent occlusion of PV branches was not achieved. The mean PV pressure elevated acutely from 17.3 mm Hg ± 0.9 to 24.5 mm Hg ± 4.2 (P <.01) after each embolization. However, the pressure always returned to baseline on the follow-up studies 1 week later. Liver function tests were normal. Histopathologic evaluation of the liver showed, in multiple PV branches, central plugs of PVA with peripheral recanalization. The liver parenchyma was otherwise normal. CONCLUSION: Massive embolizations of PV with PVA at weekly intervals failed to create permanent portal hypertension or induce hepatic fibrosis.

AB - PURPOSE: Creation of presinusoidal chronic portal venous hypertension by means of repeated portal vein (PV) embolization was explored in an attempt to improve a porcine model of transjugular intrahepatic portosystemic shunt (TIPS) patency. MATERIALS AND METHODS: Six microswine underwent weekly PV embolization for 5 weeks with a total of 10.4-12.6 g of polyvinyl alcohol (PVA) particles (0.149-0.250 mm in size). Portography, liver function tests, pressure measurement in the PV and inferior vena cava (IVC) before and after PV embolization, and histopathologic evaluation of the livers were performed. RESULTS: Transhepatic portal venography performed after each embolization demonstrated diffuse PV branch occlusion in all cases. At weekly follow-up, reconstitution of flow was demonstrated in these branches; permanent occlusion of PV branches was not achieved. The mean PV pressure elevated acutely from 17.3 mm Hg ± 0.9 to 24.5 mm Hg ± 4.2 (P <.01) after each embolization. However, the pressure always returned to baseline on the follow-up studies 1 week later. Liver function tests were normal. Histopathologic evaluation of the liver showed, in multiple PV branches, central plugs of PVA with peripheral recanalization. The liver parenchyma was otherwise normal. CONCLUSION: Massive embolizations of PV with PVA at weekly intervals failed to create permanent portal hypertension or induce hepatic fibrosis.

KW - Hypertension, portal

KW - Liver, blood supply

KW - Liver, interventional procedure

KW - Portal vein, flow dynamics

KW - Shunts, portosystemic

UR - http://www.scopus.com/inward/record.url?scp=0030810354&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030810354&partnerID=8YFLogxK

M3 - Article

C2 - 9025051

AN - SCOPUS:0030810354

VL - 8

SP - 123

EP - 128

JO - Journal of Vascular and Interventional Radiology

JF - Journal of Vascular and Interventional Radiology

SN - 1051-0443

IS - 1

ER -