TY - JOUR
T1 - Atrial natriuretic factor and pulmonary status in premature infants with respiratory distress syndrome
T2 - Preliminary investigation
AU - Pesonen, Erkki
AU - Heldt, Gregory P.
AU - Allen Merritt, T.
AU - Sahn, David J.
AU - Elias, William
AU - Tikkanen, Ilkka
AU - Fyhrquist, Frej
AU - Andersson, Sture
PY - 1993/6
Y1 - 1993/6
N2 - We studied the correlation of atrial natriuretic factor (ANF) with lung compliance in a series of 16 premature infants with respiratory distress syndrome (RDS). The infants were followed during the first week of life by sequential Doppler echocardiography, lung compliance, and ANF measurements. Plasma ANF concentration varied between 38 and 2220 pg/mL; mean concentrations of 393 and 123 pg/mL with the ductus open and with it closed, respectively (P < 0.01). The arteriolar/alveolar oxygen‐tension ratio showed an inverse correlation with the logarithm (In) of the ANF concentration (r = −0.55, P = 0.0002). Both mean airway pressure and In ANF showed an inverse correlation with the arteriolar/alveolar oxygen tension ratio (R = −0.77, F = 20.5 and 13.8, respectively). Plasma ANF was inversely correlated to lung compliance (r = −0.64, P < 0.0001). In infants with RDS, plasma ANF concentrations increase with the severity of respiratory distress. Because ANF increases endothelial permeability, in this preliminary investigation lead to the hypothesis that it may contribute to respiratory distress by causing extravasation of fluid from the pulmonary circulation in these patients. © 1993 Wiley‐Liss, Inc.
AB - We studied the correlation of atrial natriuretic factor (ANF) with lung compliance in a series of 16 premature infants with respiratory distress syndrome (RDS). The infants were followed during the first week of life by sequential Doppler echocardiography, lung compliance, and ANF measurements. Plasma ANF concentration varied between 38 and 2220 pg/mL; mean concentrations of 393 and 123 pg/mL with the ductus open and with it closed, respectively (P < 0.01). The arteriolar/alveolar oxygen‐tension ratio showed an inverse correlation with the logarithm (In) of the ANF concentration (r = −0.55, P = 0.0002). Both mean airway pressure and In ANF showed an inverse correlation with the arteriolar/alveolar oxygen tension ratio (R = −0.77, F = 20.5 and 13.8, respectively). Plasma ANF was inversely correlated to lung compliance (r = −0.64, P < 0.0001). In infants with RDS, plasma ANF concentrations increase with the severity of respiratory distress. Because ANF increases endothelial permeability, in this preliminary investigation lead to the hypothesis that it may contribute to respiratory distress by causing extravasation of fluid from the pulmonary circulation in these patients. © 1993 Wiley‐Liss, Inc.
KW - Lung compliance
KW - arteriolar/alveolar oxygen tension ratio
KW - patent ductus arteriosus
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U2 - 10.1002/ppul.1950150609
DO - 10.1002/ppul.1950150609
M3 - Article
C2 - 8337015
AN - SCOPUS:0027615923
SN - 8755-6863
VL - 15
SP - 362
EP - 364
JO - Pediatric pulmonology
JF - Pediatric pulmonology
IS - 6
ER -