Associative learning disrupted by impaired G(s) signaling in Drosophila mushroom bodies

J. B. Connolly, I. J H Roberts, J. D. Armstrong, K. Kaiser, Michael Forte, T. Tully, C. J. O'Kane

Research output: Contribution to journalArticle

378 Citations (Scopus)

Abstract

Disruptions in mushroom body (MB) or central complex (CC) brain structures impair Drosophila associative olfactory learning. Perturbations in adenosine 3',5' monophosphate signaling also disrupt learning. To integrate these observations, expression of a constitutively activated stimulatory heterotrimeric guanosine triphosphate-binding protein α subunit (Gα(s)*) was targeted to these brain structures. The ability to associate odors with electroshock was abolished when Gα(s)* was targeted to MB, but not CC, structures, whereas sensorimotor responses to these stimuli remained normal. Expression of Gα(s)* did not affect gross MB morphology, and wild-type Gα(s) expression did not affect learning. Thus, olfactory learning depends on regulated G(s) signaling in Drosophila MBs.

Original languageEnglish (US)
Pages (from-to)2104-2107
Number of pages4
JournalScience
Volume274
Issue number5295
DOIs
StatePublished - 1996

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Mushroom Bodies
Drosophila
Learning
Electroshock
Aptitude
Protein Subunits
Brain
Guanosine Triphosphate
Adenosine
Carrier Proteins

ASJC Scopus subject areas

  • General

Cite this

Connolly, J. B., Roberts, I. J. H., Armstrong, J. D., Kaiser, K., Forte, M., Tully, T., & O'Kane, C. J. (1996). Associative learning disrupted by impaired G(s) signaling in Drosophila mushroom bodies. Science, 274(5295), 2104-2107. https://doi.org/10.1126/science.274.5295.2104

Associative learning disrupted by impaired G(s) signaling in Drosophila mushroom bodies. / Connolly, J. B.; Roberts, I. J H; Armstrong, J. D.; Kaiser, K.; Forte, Michael; Tully, T.; O'Kane, C. J.

In: Science, Vol. 274, No. 5295, 1996, p. 2104-2107.

Research output: Contribution to journalArticle

Connolly, JB, Roberts, IJH, Armstrong, JD, Kaiser, K, Forte, M, Tully, T & O'Kane, CJ 1996, 'Associative learning disrupted by impaired G(s) signaling in Drosophila mushroom bodies', Science, vol. 274, no. 5295, pp. 2104-2107. https://doi.org/10.1126/science.274.5295.2104
Connolly, J. B. ; Roberts, I. J H ; Armstrong, J. D. ; Kaiser, K. ; Forte, Michael ; Tully, T. ; O'Kane, C. J. / Associative learning disrupted by impaired G(s) signaling in Drosophila mushroom bodies. In: Science. 1996 ; Vol. 274, No. 5295. pp. 2104-2107.
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