Associative learning disrupted by impaired Gs signaling in Drosophila mushroom bodies

John B. Connolly, Ian J.H. Roberts, J. Douglas Armstrong, Kim Kaiser, Michael Forte, Tim Tully, Cahir J. O'Kane

Research output: Contribution to journalArticle

387 Scopus citations

Abstract

Disruptions in mushroom body (MB) or central complex (CC) brain structures impair Drosophila associative olfactory learning. Perturbations in adenosine 3′,5′ monophosphate signaling also disrupt learning. To integrate these observations, expression of a constitutively activated stimulatory heterotrimeric guanosine triphosphate-binding protein α subunit (Gαs*) was targeted to these brain structures. The ability to associate odors with electroshock was abolished when Gαs* was targeted to MB, but not CC, structures, whereas sensorimotor responses to these stimuli remained normal. Expression of Gαs* did not affect gross MB morphology, and wild-type Gαs expression did not affect learning. Thus, olfactory learning depends on regulated Gs signaling in Drosophila MBs.

Original languageEnglish (US)
Pages (from-to)2104-2107
Number of pages4
JournalScience
Volume274
Issue number5295
DOIs
StatePublished - Dec 20 1996

    Fingerprint

ASJC Scopus subject areas

  • General

Cite this

Connolly, J. B., Roberts, I. J. H., Armstrong, J. D., Kaiser, K., Forte, M., Tully, T., & O'Kane, C. J. (1996). Associative learning disrupted by impaired Gs signaling in Drosophila mushroom bodies. Science, 274(5295), 2104-2107. https://doi.org/10.1126/science.274.5295.2104