Association of melanoma tumor antigen activity with β 2-microglobulin

A. Malley, D. R. Burger, Arthur Vandenbark, M. Frikke, P. Finke, D. Begley, K. Acott, J. Black, R. M. Vetto

Research output: Contribution to journalArticle

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Abstract

The majority of melanoma tumor antigen activity present in melanoma extracts derived from fresh tumor tissue binds to a Sepharose-anti-β2-microglobulin adsorbent. Removal of HLA antigens from the extracts of melanoma tissue by using a KBr flotation technique did not reduce either the tumor antigen activity of the extracts or the binding of melanoma tumor antigen (MTA) activity to the Sepharose-anti-β2-microglobulin adsorbent. The complete blocking of MTA activity by pretreating the anti-β2-microglobulin adsorbent with β2-microglobulin and the lack of detectable MTA binding to a Sepharose anti-normal human serum adsorbent demonstrated the specificity of the binding of MTA to the anti-β2-microglobulin adsorbent.

Original languageEnglish (US)
Pages (from-to)619-623
Number of pages5
JournalCancer Research
Volume39
Issue number2 II
StatePublished - 1979

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Melanoma-Specific Antigens
Neoplasm Antigens
Sepharose
Melanoma
Tissue Extracts
HLA Antigens
Serum
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Malley, A., Burger, D. R., Vandenbark, A., Frikke, M., Finke, P., Begley, D., ... Vetto, R. M. (1979). Association of melanoma tumor antigen activity with β 2-microglobulin. Cancer Research, 39(2 II), 619-623.

Association of melanoma tumor antigen activity with β 2-microglobulin. / Malley, A.; Burger, D. R.; Vandenbark, Arthur; Frikke, M.; Finke, P.; Begley, D.; Acott, K.; Black, J.; Vetto, R. M.

In: Cancer Research, Vol. 39, No. 2 II, 1979, p. 619-623.

Research output: Contribution to journalArticle

Malley, A, Burger, DR, Vandenbark, A, Frikke, M, Finke, P, Begley, D, Acott, K, Black, J & Vetto, RM 1979, 'Association of melanoma tumor antigen activity with β 2-microglobulin', Cancer Research, vol. 39, no. 2 II, pp. 619-623.
Malley A, Burger DR, Vandenbark A, Frikke M, Finke P, Begley D et al. Association of melanoma tumor antigen activity with β 2-microglobulin. Cancer Research. 1979;39(2 II):619-623.
Malley, A. ; Burger, D. R. ; Vandenbark, Arthur ; Frikke, M. ; Finke, P. ; Begley, D. ; Acott, K. ; Black, J. ; Vetto, R. M. / Association of melanoma tumor antigen activity with β 2-microglobulin. In: Cancer Research. 1979 ; Vol. 39, No. 2 II. pp. 619-623.
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AU - Burger, D. R.

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AU - Begley, D.

AU - Acott, K.

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AB - The majority of melanoma tumor antigen activity present in melanoma extracts derived from fresh tumor tissue binds to a Sepharose-anti-β2-microglobulin adsorbent. Removal of HLA antigens from the extracts of melanoma tissue by using a KBr flotation technique did not reduce either the tumor antigen activity of the extracts or the binding of melanoma tumor antigen (MTA) activity to the Sepharose-anti-β2-microglobulin adsorbent. The complete blocking of MTA activity by pretreating the anti-β2-microglobulin adsorbent with β2-microglobulin and the lack of detectable MTA binding to a Sepharose anti-normal human serum adsorbent demonstrated the specificity of the binding of MTA to the anti-β2-microglobulin adsorbent.

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