Association of melanoma tumor antigen activity with β 2-microglobulin

A. Malley, D. R. Burger, A. A. Vandenbark, M. Frikke, P. Finke, D. Begley, K. Acott, J. Black, R. M. Vetto

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6 Scopus citations

Abstract

The majority of melanoma tumor antigen activity present in melanoma extracts derived from fresh tumor tissue binds to a Sepharose-anti-β2-microglobulin adsorbent. Removal of HLA antigens from the extracts of melanoma tissue by using a KBr flotation technique did not reduce either the tumor antigen activity of the extracts or the binding of melanoma tumor antigen (MTA) activity to the Sepharose-anti-β2-microglobulin adsorbent. The complete blocking of MTA activity by pretreating the anti-β2-microglobulin adsorbent with β2-microglobulin and the lack of detectable MTA binding to a Sepharose anti-normal human serum adsorbent demonstrated the specificity of the binding of MTA to the anti-β2-microglobulin adsorbent.

Original languageEnglish (US)
Pages (from-to)619-623
Number of pages5
JournalCancer Research
Volume39
Issue number2 II
StatePublished - Oct 3 1979

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Malley, A., Burger, D. R., Vandenbark, A. A., Frikke, M., Finke, P., Begley, D., Acott, K., Black, J., & Vetto, R. M. (1979). Association of melanoma tumor antigen activity with β 2-microglobulin. Cancer Research, 39(2 II), 619-623.