Association of codon 72 polymorphism of p53 with lower prostate cancer risk

Wm David Henner, Adam J. Evans, Kristi M. Hough, Emily L. Harris, Bruce A. Lowe, Tomasz (Tom) Beer

    Research output: Contribution to journalArticle

    57 Citations (Scopus)

    Abstract

    BACKGROUND. A common germline polymorphism of p53 produces a protein with an Arg to Pro change at codon 72. This Pro variant has altered biochemical properties suggesting altered cancer susceptibility. METHODS. A case control study with 115 men with prostate cancer and 181 community control male subjects was conducted. Demographics, family history of cancer, and blood were obtained. Codon 72 genotypes were determined using PCR. RESULTS. The Pro/Pro genotype was associated with a markedly lower risk of prostate cancer (OR = 0.23, CI = 0.07-0.79, P = 0.012). Similar reduction in risk was observed when the analysis was limited to Caucasian subjects (86% of total). Reduction in risk remained significant in a logistic regression model after correcting for age and family history of prostate cancer (OR = 0.14, CI = 0.03-0.71, P = 0.017). CONCLUSIONS. Men with the p53 codon 72 Pro/Pro genotype appear to be at reduced risk of prostate cancer.

    Original languageEnglish (US)
    Pages (from-to)263-266
    Number of pages4
    JournalProstate
    Volume49
    Issue number4
    DOIs
    StatePublished - 2001

    Fingerprint

    Codon
    Prostatic Neoplasms
    Genotype
    Risk Reduction Behavior
    Logistic Models
    Case-Control Studies
    Neoplasms
    Demography
    Polymerase Chain Reaction
    Proteins

    Keywords

    • Epidemiology
    • p53
    • Polymorphism
    • Prostate cancer

    ASJC Scopus subject areas

    • Urology

    Cite this

    Henner, W. D., Evans, A. J., Hough, K. M., Harris, E. L., Lowe, B. A., & Beer, T. T. (2001). Association of codon 72 polymorphism of p53 with lower prostate cancer risk. Prostate, 49(4), 263-266. https://doi.org/10.1002/pros.10021

    Association of codon 72 polymorphism of p53 with lower prostate cancer risk. / Henner, Wm David; Evans, Adam J.; Hough, Kristi M.; Harris, Emily L.; Lowe, Bruce A.; Beer, Tomasz (Tom).

    In: Prostate, Vol. 49, No. 4, 2001, p. 263-266.

    Research output: Contribution to journalArticle

    Henner, WD, Evans, AJ, Hough, KM, Harris, EL, Lowe, BA & Beer, TT 2001, 'Association of codon 72 polymorphism of p53 with lower prostate cancer risk', Prostate, vol. 49, no. 4, pp. 263-266. https://doi.org/10.1002/pros.10021
    Henner, Wm David ; Evans, Adam J. ; Hough, Kristi M. ; Harris, Emily L. ; Lowe, Bruce A. ; Beer, Tomasz (Tom). / Association of codon 72 polymorphism of p53 with lower prostate cancer risk. In: Prostate. 2001 ; Vol. 49, No. 4. pp. 263-266.
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    abstract = "BACKGROUND. A common germline polymorphism of p53 produces a protein with an Arg to Pro change at codon 72. This Pro variant has altered biochemical properties suggesting altered cancer susceptibility. METHODS. A case control study with 115 men with prostate cancer and 181 community control male subjects was conducted. Demographics, family history of cancer, and blood were obtained. Codon 72 genotypes were determined using PCR. RESULTS. The Pro/Pro genotype was associated with a markedly lower risk of prostate cancer (OR = 0.23, CI = 0.07-0.79, P = 0.012). Similar reduction in risk was observed when the analysis was limited to Caucasian subjects (86{\%} of total). Reduction in risk remained significant in a logistic regression model after correcting for age and family history of prostate cancer (OR = 0.14, CI = 0.03-0.71, P = 0.017). CONCLUSIONS. Men with the p53 codon 72 Pro/Pro genotype appear to be at reduced risk of prostate cancer.",
    keywords = "Epidemiology, p53, Polymorphism, Prostate cancer",
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    AU - Henner, Wm David

    AU - Evans, Adam J.

    AU - Hough, Kristi M.

    AU - Harris, Emily L.

    AU - Lowe, Bruce A.

    AU - Beer, Tomasz (Tom)

    PY - 2001

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    N2 - BACKGROUND. A common germline polymorphism of p53 produces a protein with an Arg to Pro change at codon 72. This Pro variant has altered biochemical properties suggesting altered cancer susceptibility. METHODS. A case control study with 115 men with prostate cancer and 181 community control male subjects was conducted. Demographics, family history of cancer, and blood were obtained. Codon 72 genotypes were determined using PCR. RESULTS. The Pro/Pro genotype was associated with a markedly lower risk of prostate cancer (OR = 0.23, CI = 0.07-0.79, P = 0.012). Similar reduction in risk was observed when the analysis was limited to Caucasian subjects (86% of total). Reduction in risk remained significant in a logistic regression model after correcting for age and family history of prostate cancer (OR = 0.14, CI = 0.03-0.71, P = 0.017). CONCLUSIONS. Men with the p53 codon 72 Pro/Pro genotype appear to be at reduced risk of prostate cancer.

    AB - BACKGROUND. A common germline polymorphism of p53 produces a protein with an Arg to Pro change at codon 72. This Pro variant has altered biochemical properties suggesting altered cancer susceptibility. METHODS. A case control study with 115 men with prostate cancer and 181 community control male subjects was conducted. Demographics, family history of cancer, and blood were obtained. Codon 72 genotypes were determined using PCR. RESULTS. The Pro/Pro genotype was associated with a markedly lower risk of prostate cancer (OR = 0.23, CI = 0.07-0.79, P = 0.012). Similar reduction in risk was observed when the analysis was limited to Caucasian subjects (86% of total). Reduction in risk remained significant in a logistic regression model after correcting for age and family history of prostate cancer (OR = 0.14, CI = 0.03-0.71, P = 0.017). CONCLUSIONS. Men with the p53 codon 72 Pro/Pro genotype appear to be at reduced risk of prostate cancer.

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    KW - Polymorphism

    KW - Prostate cancer

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